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Relevance of Alternative Routes of Kynurenic Acid Production in the Brain
المؤلفون المشاركون
Lugo-Huitrón, Rafael
Silva-Adaya, Daniela
González-Esquivel, Dinora
Ríos, Camilo
Ramos-Chávez, L. A.
Sánchez-Chapul, L.
Roldán-Roldán, G.
Pineda, Benjamín
Pérez-de la Cruz, Verónica
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-24
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The catabolism of tryptophan has gained great importance in recent years due to the fact that the metabolites produced during this process, with neuroactive and redox properties, are involved in physiological and pathological events.
One of these metabolites is kynurenic acid (KYNA), which is considered as a neuromodulator since it can interact with NMDA, nicotinic, and GPR35 receptors among others, modulating the release of neurotransmitters as glutamate, dopamine, and acetylcholine.
Kynureninate production is attributed to kynurenine aminotransferases.
However, in some physiological and pathological conditions, its high production cannot be explained just with kynurenine aminotransferases.
This review focuses on the alternative mechanism whereby KYNA can be produced, either from D-amino acids or by means of other enzymes as D-amino acid oxidase or by the participation of free radicals.
It is important to mention that an increase in KYNA levels in processes as brain development, aging, neurodegenerative diseases, and psychiatric disorders, which share common factors as oxidative stress, inflammation, immune response activation, and participation of gut microbiota that can also be related with the alternative routes of KYNA production, has been observed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ramos-Chávez, L. A.& Lugo-Huitrón, Rafael& González-Esquivel, Dinora& Pineda, Benjamín& Ríos, Camilo& Silva-Adaya, Daniela…[et al.]. 2018. Relevance of Alternative Routes of Kynurenic Acid Production in the Brain. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1211596
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ramos-Chávez, L. A.…[et al.]. Relevance of Alternative Routes of Kynurenic Acid Production in the Brain. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1211596
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ramos-Chávez, L. A.& Lugo-Huitrón, Rafael& González-Esquivel, Dinora& Pineda, Benjamín& Ríos, Camilo& Silva-Adaya, Daniela…[et al.]. Relevance of Alternative Routes of Kynurenic Acid Production in the Brain. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1211596
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211596
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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