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Relevance of Alternative Routes of Kynurenic Acid Production in the Brain
Joint Authors
Lugo-Huitrón, Rafael
Silva-Adaya, Daniela
González-Esquivel, Dinora
Ríos, Camilo
Ramos-Chávez, L. A.
Sánchez-Chapul, L.
Roldán-Roldán, G.
Pineda, Benjamín
Pérez-de la Cruz, Verónica
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-24
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The catabolism of tryptophan has gained great importance in recent years due to the fact that the metabolites produced during this process, with neuroactive and redox properties, are involved in physiological and pathological events.
One of these metabolites is kynurenic acid (KYNA), which is considered as a neuromodulator since it can interact with NMDA, nicotinic, and GPR35 receptors among others, modulating the release of neurotransmitters as glutamate, dopamine, and acetylcholine.
Kynureninate production is attributed to kynurenine aminotransferases.
However, in some physiological and pathological conditions, its high production cannot be explained just with kynurenine aminotransferases.
This review focuses on the alternative mechanism whereby KYNA can be produced, either from D-amino acids or by means of other enzymes as D-amino acid oxidase or by the participation of free radicals.
It is important to mention that an increase in KYNA levels in processes as brain development, aging, neurodegenerative diseases, and psychiatric disorders, which share common factors as oxidative stress, inflammation, immune response activation, and participation of gut microbiota that can also be related with the alternative routes of KYNA production, has been observed.
American Psychological Association (APA)
Ramos-Chávez, L. A.& Lugo-Huitrón, Rafael& González-Esquivel, Dinora& Pineda, Benjamín& Ríos, Camilo& Silva-Adaya, Daniela…[et al.]. 2018. Relevance of Alternative Routes of Kynurenic Acid Production in the Brain. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1211596
Modern Language Association (MLA)
Ramos-Chávez, L. A.…[et al.]. Relevance of Alternative Routes of Kynurenic Acid Production in the Brain. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1211596
American Medical Association (AMA)
Ramos-Chávez, L. A.& Lugo-Huitrón, Rafael& González-Esquivel, Dinora& Pineda, Benjamín& Ríos, Camilo& Silva-Adaya, Daniela…[et al.]. Relevance of Alternative Routes of Kynurenic Acid Production in the Brain. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1211596
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211596