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Exposure of Drosophila melanogaster to Mancozeb Induces Oxidative Damage and Modulates Nrf2 and HSP7083
المؤلفون المشاركون
Vieira, Patrícia de Brum
Felipe da Silva, Gustavo
Echeverria Macedo, Giulianna
Kemmerich Martins, Illana
Franco, Jeferson Luis
Posser, Thaís
Rodrigues, Nathane Rosa
de Carvalho, Nelson Rodrigues
Saraiva, Miriane Acosta
da Rosa Ávila, Eduardo
Nascimento, Mariele Samuel
Picoloto, Rochele Sogari
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-05
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Mancozeb (MZ), a manganese- and zinc-containing ethylene-bis-dithiocarbamate, is a broad-spectrum fungicide.
Harmful effects of this fungicide have been reported in nontarget organisms via a not fully understood mechanism.
Drosophila melanogaster has provided remarkable contributions for toxicological studies.
This work was aimed at evaluating the biochemical targets and implication of oxidative stress in MZ-mediated toxicity in drosophilas.
Exposure of flies for fifteen days to MZ at 5 and 10 mg/mL through the diet impaired locomotor performance and induced fly mortality.
In parallel, it caused lipid peroxidation and reactive oxygen species (ROS) formation and Mn overload.
MZ inhibited superoxide dismutase and inducted catalase and glutathione S-transferase activities.
Nitric oxide and reduced glutathione levels were significantly decreased by MZ.
Heat shock proteins (HSP70 and HSP83) and Nrf2 mRNA levels were significantly augmented in MZ-exposed flies.
Our study reinforced the use of Drosophila melanogaster as a reliable model for the study of biochemical targets of pesticides, and based on our data, MZ induced oxidative damage and Mn accumulation in a concentration-dependent manner.
An adaptative cellular state was inducted by the lower concentration of pesticide, possibly contributing to the slighter damage observed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Saraiva, Miriane Acosta& da Rosa Ávila, Eduardo& Felipe da Silva, Gustavo& Echeverria Macedo, Giulianna& Rodrigues, Nathane Rosa& Vieira, Patrícia de Brum…[et al.]. 2018. Exposure of Drosophila melanogaster to Mancozeb Induces Oxidative Damage and Modulates Nrf2 and HSP7083. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211633
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Saraiva, Miriane Acosta…[et al.]. Exposure of Drosophila melanogaster to Mancozeb Induces Oxidative Damage and Modulates Nrf2 and HSP7083. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1211633
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Saraiva, Miriane Acosta& da Rosa Ávila, Eduardo& Felipe da Silva, Gustavo& Echeverria Macedo, Giulianna& Rodrigues, Nathane Rosa& Vieira, Patrícia de Brum…[et al.]. Exposure of Drosophila melanogaster to Mancozeb Induces Oxidative Damage and Modulates Nrf2 and HSP7083. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211633
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211633
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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