Exposure of Drosophila melanogaster to Mancozeb Induces Oxidative Damage and Modulates Nrf2 and HSP7083
Joint Authors
Vieira, Patrícia de Brum
Felipe da Silva, Gustavo
Echeverria Macedo, Giulianna
Kemmerich Martins, Illana
Franco, Jeferson Luis
Posser, Thaís
Rodrigues, Nathane Rosa
de Carvalho, Nelson Rodrigues
Saraiva, Miriane Acosta
da Rosa Ávila, Eduardo
Nascimento, Mariele Samuel
Picoloto, Rochele Sogari
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Mancozeb (MZ), a manganese- and zinc-containing ethylene-bis-dithiocarbamate, is a broad-spectrum fungicide.
Harmful effects of this fungicide have been reported in nontarget organisms via a not fully understood mechanism.
Drosophila melanogaster has provided remarkable contributions for toxicological studies.
This work was aimed at evaluating the biochemical targets and implication of oxidative stress in MZ-mediated toxicity in drosophilas.
Exposure of flies for fifteen days to MZ at 5 and 10 mg/mL through the diet impaired locomotor performance and induced fly mortality.
In parallel, it caused lipid peroxidation and reactive oxygen species (ROS) formation and Mn overload.
MZ inhibited superoxide dismutase and inducted catalase and glutathione S-transferase activities.
Nitric oxide and reduced glutathione levels were significantly decreased by MZ.
Heat shock proteins (HSP70 and HSP83) and Nrf2 mRNA levels were significantly augmented in MZ-exposed flies.
Our study reinforced the use of Drosophila melanogaster as a reliable model for the study of biochemical targets of pesticides, and based on our data, MZ induced oxidative damage and Mn accumulation in a concentration-dependent manner.
An adaptative cellular state was inducted by the lower concentration of pesticide, possibly contributing to the slighter damage observed.
American Psychological Association (APA)
Saraiva, Miriane Acosta& da Rosa Ávila, Eduardo& Felipe da Silva, Gustavo& Echeverria Macedo, Giulianna& Rodrigues, Nathane Rosa& Vieira, Patrícia de Brum…[et al.]. 2018. Exposure of Drosophila melanogaster to Mancozeb Induces Oxidative Damage and Modulates Nrf2 and HSP7083. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211633
Modern Language Association (MLA)
Saraiva, Miriane Acosta…[et al.]. Exposure of Drosophila melanogaster to Mancozeb Induces Oxidative Damage and Modulates Nrf2 and HSP7083. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1211633
American Medical Association (AMA)
Saraiva, Miriane Acosta& da Rosa Ávila, Eduardo& Felipe da Silva, Gustavo& Echeverria Macedo, Giulianna& Rodrigues, Nathane Rosa& Vieira, Patrícia de Brum…[et al.]. Exposure of Drosophila melanogaster to Mancozeb Induces Oxidative Damage and Modulates Nrf2 and HSP7083. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211633
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211633