A Typical Immune TB Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status?
المؤلفون المشاركون
Mazzesi, Giuseppe
Marullo, Antonino G. M.
Colonna-Romano, Giuseppina
Lio, Domenico
Greco, Ernesto
Sciarretta, Sebastiano
Frati, G.
Cavarretta, Elena
Buffa, Silvio
Ruvolo, Giovanni
Palmerio, Silvia
Allegra, Alberto
Pisano, Calogera
Schiavon, Sonia
Balistreri, Carmela Rita
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-05
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Bicuspid valve disease is associated with the development of thoracic aortic aneurysm.
The molecular mechanisms underlying this association still need to be clarified.
Here, we evaluated the circulating levels of T and B lymphocyte subsets associated with the development of vascular diseases in patients with bicuspid aortic valve or tricuspid aortic valve with and without thoracic aortic aneurysm.
We unveiled that the circulating levels of the MAIT, CD4+IL−17A+, and NKT T cell subsets were significantly reduced in bicuspid valve disease cases, when compared to tricuspid aortic valve cases in either the presence or the absence of thoracic aortic aneurysm.
Among patients with tricuspid aortic valve, these cells were higher in those also affected by thoracic aortic aneurysm.
Similar data were obtained by examining CD19+ B cells, naïve B cells (IgD+CD27−), memory unswitched B cells (IgD+CD27+), memory switched B cells (IgD−CD27+), and double-negative B cells (DN) (IgD−CD27−).
These cells resulted to be lower in subjects with bicuspid valve disease with respect to patients with tricuspid aortic valve.
In whole, our data indicate that patients with bicuspid valve disease show a quantitative reduction of T and B lymphocyte cell subsets.
Future studies are encouraged to understand the molecular mechanisms underlying this observation and its pathophysiological significance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Balistreri, Carmela Rita& Buffa, Silvio& Allegra, Alberto& Pisano, Calogera& Ruvolo, Giovanni& Colonna-Romano, Giuseppina…[et al.]. 2018. A Typical Immune TB Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status?. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1211689
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Balistreri, Carmela Rita…[et al.]. A Typical Immune TB Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status?. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1211689
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Balistreri, Carmela Rita& Buffa, Silvio& Allegra, Alberto& Pisano, Calogera& Ruvolo, Giovanni& Colonna-Romano, Giuseppina…[et al.]. A Typical Immune TB Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status?. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1211689
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211689
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر