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A Typical Immune TB Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status?
Joint Authors
Mazzesi, Giuseppe
Marullo, Antonino G. M.
Colonna-Romano, Giuseppina
Lio, Domenico
Greco, Ernesto
Sciarretta, Sebastiano
Frati, G.
Cavarretta, Elena
Buffa, Silvio
Ruvolo, Giovanni
Palmerio, Silvia
Allegra, Alberto
Pisano, Calogera
Schiavon, Sonia
Balistreri, Carmela Rita
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Bicuspid valve disease is associated with the development of thoracic aortic aneurysm.
The molecular mechanisms underlying this association still need to be clarified.
Here, we evaluated the circulating levels of T and B lymphocyte subsets associated with the development of vascular diseases in patients with bicuspid aortic valve or tricuspid aortic valve with and without thoracic aortic aneurysm.
We unveiled that the circulating levels of the MAIT, CD4+IL−17A+, and NKT T cell subsets were significantly reduced in bicuspid valve disease cases, when compared to tricuspid aortic valve cases in either the presence or the absence of thoracic aortic aneurysm.
Among patients with tricuspid aortic valve, these cells were higher in those also affected by thoracic aortic aneurysm.
Similar data were obtained by examining CD19+ B cells, naïve B cells (IgD+CD27−), memory unswitched B cells (IgD+CD27+), memory switched B cells (IgD−CD27+), and double-negative B cells (DN) (IgD−CD27−).
These cells resulted to be lower in subjects with bicuspid valve disease with respect to patients with tricuspid aortic valve.
In whole, our data indicate that patients with bicuspid valve disease show a quantitative reduction of T and B lymphocyte cell subsets.
Future studies are encouraged to understand the molecular mechanisms underlying this observation and its pathophysiological significance.
American Psychological Association (APA)
Balistreri, Carmela Rita& Buffa, Silvio& Allegra, Alberto& Pisano, Calogera& Ruvolo, Giovanni& Colonna-Romano, Giuseppina…[et al.]. 2018. A Typical Immune TB Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status?. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1211689
Modern Language Association (MLA)
Balistreri, Carmela Rita…[et al.]. A Typical Immune TB Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status?. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1211689
American Medical Association (AMA)
Balistreri, Carmela Rita& Buffa, Silvio& Allegra, Alberto& Pisano, Calogera& Ruvolo, Giovanni& Colonna-Romano, Giuseppina…[et al.]. A Typical Immune TB Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status?. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1211689
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211689