High-Fat Diet Increases HMGB1 Expression and Promotes Lung Inflammation in Mice Subjected to Mechanical Ventilation
المؤلفون المشاركون
Talvani, André
Paula Costa, Guilherme de
Bezerra, Frank Silva
de Souza, Ana Beatriz Farias
Chírico, Máira Tereza Talma
Cartelle, Christiane Teixeira
Cangussú, Sílvia Dantas
de Menezes, Rodrigo Cunha Alvim
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
This study aims to evaluate the effects of a high-fat diet and mechanical ventilation on the pulmonary and systemic inflammatory response in C57BL/6 mice.
Male C57BL/6 mice were divided into two groups: one received a standard diet, and the other received a high-fat diet.
After 10 weeks, the groups were further divided into two groups each: control group (CG), mechanical ventilation group (MVG), diet group (DG), and diet mechanical ventilation group (DMVG).
MVG and DMVG underwent mechanical ventilation for 60 minutes.
All animals were euthanized for subsequent analysis.
Animals receiving a high-fat diet presented higher body mass, adipose index, and greater adipocyte area.
In the lung, the expression of HMGB1 was greater in DG and DMVG than in CG and MVG.
CCL2 and IL-22 levels in MVG and DMVG were increased compared to those in CG and DG, whereas IL-10 and IL-17 were decreased.
Superoxide dismutase activity was higher in MVG and DMVG than in CG.
Catalase activity was lower in DG than in CG, and in MV groups, it was lower than that in CG and DG.
MV and obesity promote inflammation and pulmonary oxidative stress in adult C57BL/6 mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Souza, Ana Beatriz Farias& Chírico, Máira Tereza Talma& Cartelle, Christiane Teixeira& Paula Costa, Guilherme de& Talvani, André& Cangussú, Sílvia Dantas…[et al.]. 2018. High-Fat Diet Increases HMGB1 Expression and Promotes Lung Inflammation in Mice Subjected to Mechanical Ventilation. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211994
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Souza, Ana Beatriz Farias…[et al.]. High-Fat Diet Increases HMGB1 Expression and Promotes Lung Inflammation in Mice Subjected to Mechanical Ventilation. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1211994
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Souza, Ana Beatriz Farias& Chírico, Máira Tereza Talma& Cartelle, Christiane Teixeira& Paula Costa, Guilherme de& Talvani, André& Cangussú, Sílvia Dantas…[et al.]. High-Fat Diet Increases HMGB1 Expression and Promotes Lung Inflammation in Mice Subjected to Mechanical Ventilation. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211994
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211994
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر