High-Fat Diet Increases HMGB1 Expression and Promotes Lung Inflammation in Mice Subjected to Mechanical Ventilation
Joint Authors
Talvani, André
Paula Costa, Guilherme de
Bezerra, Frank Silva
de Souza, Ana Beatriz Farias
Chírico, Máira Tereza Talma
Cartelle, Christiane Teixeira
Cangussú, Sílvia Dantas
de Menezes, Rodrigo Cunha Alvim
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This study aims to evaluate the effects of a high-fat diet and mechanical ventilation on the pulmonary and systemic inflammatory response in C57BL/6 mice.
Male C57BL/6 mice were divided into two groups: one received a standard diet, and the other received a high-fat diet.
After 10 weeks, the groups were further divided into two groups each: control group (CG), mechanical ventilation group (MVG), diet group (DG), and diet mechanical ventilation group (DMVG).
MVG and DMVG underwent mechanical ventilation for 60 minutes.
All animals were euthanized for subsequent analysis.
Animals receiving a high-fat diet presented higher body mass, adipose index, and greater adipocyte area.
In the lung, the expression of HMGB1 was greater in DG and DMVG than in CG and MVG.
CCL2 and IL-22 levels in MVG and DMVG were increased compared to those in CG and DG, whereas IL-10 and IL-17 were decreased.
Superoxide dismutase activity was higher in MVG and DMVG than in CG.
Catalase activity was lower in DG than in CG, and in MV groups, it was lower than that in CG and DG.
MV and obesity promote inflammation and pulmonary oxidative stress in adult C57BL/6 mice.
American Psychological Association (APA)
de Souza, Ana Beatriz Farias& Chírico, Máira Tereza Talma& Cartelle, Christiane Teixeira& Paula Costa, Guilherme de& Talvani, André& Cangussú, Sílvia Dantas…[et al.]. 2018. High-Fat Diet Increases HMGB1 Expression and Promotes Lung Inflammation in Mice Subjected to Mechanical Ventilation. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211994
Modern Language Association (MLA)
de Souza, Ana Beatriz Farias…[et al.]. High-Fat Diet Increases HMGB1 Expression and Promotes Lung Inflammation in Mice Subjected to Mechanical Ventilation. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1211994
American Medical Association (AMA)
de Souza, Ana Beatriz Farias& Chírico, Máira Tereza Talma& Cartelle, Christiane Teixeira& Paula Costa, Guilherme de& Talvani, André& Cangussú, Sílvia Dantas…[et al.]. High-Fat Diet Increases HMGB1 Expression and Promotes Lung Inflammation in Mice Subjected to Mechanical Ventilation. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211994
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211994