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Urinary 1H-NMR Metabolomics in the First Week of Life Can Anticipate BPD Diagnosis
المؤلفون المشاركون
Dessì, Angelica
Fanos, V.
Pintus, Roberta
Pintus, Maria Cristina
Lussu, Milena
Noto, Antonio
Masile, Valentina
Marcialis, Maria Antonietta
Puddu, Melania
Atzori, L.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-28
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Despite the advancements in medical knowledge and technology, the etiopathogenesis of bronchopulmonary dysplasia (BPD) is not yet fully understood although oxidative stress seems to play a role, leading to a very demanding management of these patients by the neonatologist.
In this context, metabolomics can be useful in understanding, diagnosing, and treating this illness since it is one of the newest omics science that analyzes the metabolome of an individual through the investigation of biological fluids such as urine and blood.
In this study, 18 patients admitted to the Neonatal Intensive Care Unit of the Cagliari University Hospital were enrolled.
Among them, 11 patients represented the control group and 7 patients subsequently developed BPD.
A sample of urine was collected from each patient at 7 days of life and analyzed through 1H-NMR coupled with multivariate statistical analysis.
The discriminant metabolites between the 2 groups noted were alanine, betaine, trimethylamine-N-oxide, lactate, and glycine.
Utilizing metabolomics, it was possible to detect the urinary metabolomics fingerprint of neonates in the first week of life who subsequently developed BPD.
Future studies are needed to confirm these promising results suggesting a possible role of microbiota and oxidative stress, and to apply this technology in clinical practice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pintus, Maria Cristina& Lussu, Milena& Dessì, Angelica& Pintus, Roberta& Noto, Antonio& Masile, Valentina…[et al.]. 2018. Urinary 1H-NMR Metabolomics in the First Week of Life Can Anticipate BPD Diagnosis. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1212054
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pintus, Maria Cristina…[et al.]. Urinary 1H-NMR Metabolomics in the First Week of Life Can Anticipate BPD Diagnosis. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1212054
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pintus, Maria Cristina& Lussu, Milena& Dessì, Angelica& Pintus, Roberta& Noto, Antonio& Masile, Valentina…[et al.]. Urinary 1H-NMR Metabolomics in the First Week of Life Can Anticipate BPD Diagnosis. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1212054
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212054
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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