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Urinary 1H-NMR Metabolomics in the First Week of Life Can Anticipate BPD Diagnosis
Joint Authors
Dessì, Angelica
Fanos, V.
Pintus, Roberta
Pintus, Maria Cristina
Lussu, Milena
Noto, Antonio
Masile, Valentina
Marcialis, Maria Antonietta
Puddu, Melania
Atzori, L.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Despite the advancements in medical knowledge and technology, the etiopathogenesis of bronchopulmonary dysplasia (BPD) is not yet fully understood although oxidative stress seems to play a role, leading to a very demanding management of these patients by the neonatologist.
In this context, metabolomics can be useful in understanding, diagnosing, and treating this illness since it is one of the newest omics science that analyzes the metabolome of an individual through the investigation of biological fluids such as urine and blood.
In this study, 18 patients admitted to the Neonatal Intensive Care Unit of the Cagliari University Hospital were enrolled.
Among them, 11 patients represented the control group and 7 patients subsequently developed BPD.
A sample of urine was collected from each patient at 7 days of life and analyzed through 1H-NMR coupled with multivariate statistical analysis.
The discriminant metabolites between the 2 groups noted were alanine, betaine, trimethylamine-N-oxide, lactate, and glycine.
Utilizing metabolomics, it was possible to detect the urinary metabolomics fingerprint of neonates in the first week of life who subsequently developed BPD.
Future studies are needed to confirm these promising results suggesting a possible role of microbiota and oxidative stress, and to apply this technology in clinical practice.
American Psychological Association (APA)
Pintus, Maria Cristina& Lussu, Milena& Dessì, Angelica& Pintus, Roberta& Noto, Antonio& Masile, Valentina…[et al.]. 2018. Urinary 1H-NMR Metabolomics in the First Week of Life Can Anticipate BPD Diagnosis. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1212054
Modern Language Association (MLA)
Pintus, Maria Cristina…[et al.]. Urinary 1H-NMR Metabolomics in the First Week of Life Can Anticipate BPD Diagnosis. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1212054
American Medical Association (AMA)
Pintus, Maria Cristina& Lussu, Milena& Dessì, Angelica& Pintus, Roberta& Noto, Antonio& Masile, Valentina…[et al.]. Urinary 1H-NMR Metabolomics in the First Week of Life Can Anticipate BPD Diagnosis. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1212054
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212054