![](/images/graphics-bg.png)
Autophagy Modulation in Cancer: Current Knowledge on Action and Therapy
المؤلفون المشاركون
Marinković, Mija
Šprung, Matilda
Buljubašić, Maja
Novak, Ivana
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-31
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
In the last two decades, accumulating evidence pointed to the importance of autophagy in various human diseases.
As an essential evolutionary catabolic process of cytoplasmatic component digestion, it is generally believed that modulating autophagic activity, through targeting specific regulatory actors in the core autophagy machinery, may impact disease processes.
Both autophagy upregulation and downregulation have been found in cancers, suggesting its dual oncogenic and tumor suppressor properties during malignant transformation.
Identification of the key autophagy targets is essential for the development of new therapeutic agents.
Despite this great potential, no therapies are currently available that specifically focus on autophagy modulation.
Although drugs like rapamycin, chloroquine, hydroxychloroquine, and others act as autophagy modulators, they were not originally developed for this purpose.
Thus, autophagy may represent a new and promising pharmacologic target for future drug development and therapeutic applications in human diseases.
Here, we summarize our current knowledge in regard to the interplay between autophagy and malignancy in the most significant tumor types: pancreatic, breast, hepatocellular, colorectal, and lung cancer, which have been studied in respect to autophagy manipulation as a promising therapeutic strategy.
Finally, we present an overview of the most recent advances in therapeutic strategies involving autophagy modulators in cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Marinković, Mija& Šprung, Matilda& Buljubašić, Maja& Novak, Ivana. 2018. Autophagy Modulation in Cancer: Current Knowledge on Action and Therapy. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1212141
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Marinković, Mija…[et al.]. Autophagy Modulation in Cancer: Current Knowledge on Action and Therapy. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1212141
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Marinković, Mija& Šprung, Matilda& Buljubašić, Maja& Novak, Ivana. Autophagy Modulation in Cancer: Current Knowledge on Action and Therapy. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1212141
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212141
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)