Autophagy Modulation in Cancer: Current Knowledge on Action and Therapy
Joint Authors
Marinković, Mija
Šprung, Matilda
Buljubašić, Maja
Novak, Ivana
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-31
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
In the last two decades, accumulating evidence pointed to the importance of autophagy in various human diseases.
As an essential evolutionary catabolic process of cytoplasmatic component digestion, it is generally believed that modulating autophagic activity, through targeting specific regulatory actors in the core autophagy machinery, may impact disease processes.
Both autophagy upregulation and downregulation have been found in cancers, suggesting its dual oncogenic and tumor suppressor properties during malignant transformation.
Identification of the key autophagy targets is essential for the development of new therapeutic agents.
Despite this great potential, no therapies are currently available that specifically focus on autophagy modulation.
Although drugs like rapamycin, chloroquine, hydroxychloroquine, and others act as autophagy modulators, they were not originally developed for this purpose.
Thus, autophagy may represent a new and promising pharmacologic target for future drug development and therapeutic applications in human diseases.
Here, we summarize our current knowledge in regard to the interplay between autophagy and malignancy in the most significant tumor types: pancreatic, breast, hepatocellular, colorectal, and lung cancer, which have been studied in respect to autophagy manipulation as a promising therapeutic strategy.
Finally, we present an overview of the most recent advances in therapeutic strategies involving autophagy modulators in cancer.
American Psychological Association (APA)
Marinković, Mija& Šprung, Matilda& Buljubašić, Maja& Novak, Ivana. 2018. Autophagy Modulation in Cancer: Current Knowledge on Action and Therapy. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1212141
Modern Language Association (MLA)
Marinković, Mija…[et al.]. Autophagy Modulation in Cancer: Current Knowledge on Action and Therapy. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1212141
American Medical Association (AMA)
Marinković, Mija& Šprung, Matilda& Buljubašić, Maja& Novak, Ivana. Autophagy Modulation in Cancer: Current Knowledge on Action and Therapy. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1212141
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212141