![](/images/graphics-bg.png)
Eugenol as a Promising Molecule for the Treatment of Dermatitis: Antioxidant and Anti-inflammatory Activities and Its Nanoformulation
المؤلفون المشاركون
Freitas, Lyara Barbosa Nogueira
de Araújo Lopes, Amanda
da Fonseca, Francisco Noé
Rocha, Talita Magalhães
Araújo, Emmanuel Vinicius Oliveira
Wong, Deysi Viviana Tenazoa
Lima Júnior, Roberto César Pereira
Leal, Luzia Kalyne Almeida Moreira
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-11
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Contact dermatitis produces an inflammatory reaction primarily via stimulation of keratinocytes and cells of the immune system, which promote the release of cytokines, reactive oxygen species (ROS), and other chemical mediators.
Eugenol (EUG, phenylpropanoid of essential oils) has attracted attention due to its anti-inflammatory properties, as well as antioxidant effect.
On the other hand, it is volatile and insoluble and is a skin irritant.
In this case, nanostructured systems have been successfully employed as a drug carrier for skin diseases since they improve both biological and pharmaceutical properties of active compounds.
The cytotoxic, antioxidant, and anti-inflammatory effects of EUG were assessed in human neutrophils and keratinocytes.
Additionally, polymeric nanocarries (NCEUG) were prepared to improve the chemical and irritant characteristics of EUG.
EUG presented apparent safety and antioxidant and anti-inflammatory effects on human neutrophils, but presented cytotoxic effects on keratinocytes.
However, the nanocapsules were able to reduce its cytotoxicity.
An in vivo experiment of irritant contact dermatitis (ICD) in mice induced by TPA showed that NCEUG reduced significantly the ear edema in mice when compared to the EUG solution, as well as the leukocyte infiltration and IL-6 level, possibly due to better skin permeation and irritancy blockage.
These findings suggest that EUG is a promising bioactive molecule, and its nanoencapsulation seems to be an interesting approach for the treatment of ICD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Araújo Lopes, Amanda& da Fonseca, Francisco Noé& Rocha, Talita Magalhães& Freitas, Lyara Barbosa Nogueira & Araújo, Emmanuel Vinicius Oliveira& Wong, Deysi Viviana Tenazoa…[et al.]. 2018. Eugenol as a Promising Molecule for the Treatment of Dermatitis: Antioxidant and Anti-inflammatory Activities and Its Nanoformulation. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1212163
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Araújo Lopes, Amanda…[et al.]. Eugenol as a Promising Molecule for the Treatment of Dermatitis: Antioxidant and Anti-inflammatory Activities and Its Nanoformulation. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1212163
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Araújo Lopes, Amanda& da Fonseca, Francisco Noé& Rocha, Talita Magalhães& Freitas, Lyara Barbosa Nogueira & Araújo, Emmanuel Vinicius Oliveira& Wong, Deysi Viviana Tenazoa…[et al.]. Eugenol as a Promising Molecule for the Treatment of Dermatitis: Antioxidant and Anti-inflammatory Activities and Its Nanoformulation. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1212163
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212163
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)