Eugenol as a Promising Molecule for the Treatment of Dermatitis: Antioxidant and Anti-inflammatory Activities and Its Nanoformulation
Joint Authors
Freitas, Lyara Barbosa Nogueira
de Araújo Lopes, Amanda
da Fonseca, Francisco Noé
Rocha, Talita Magalhães
Araújo, Emmanuel Vinicius Oliveira
Wong, Deysi Viviana Tenazoa
Lima Júnior, Roberto César Pereira
Leal, Luzia Kalyne Almeida Moreira
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-11
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Contact dermatitis produces an inflammatory reaction primarily via stimulation of keratinocytes and cells of the immune system, which promote the release of cytokines, reactive oxygen species (ROS), and other chemical mediators.
Eugenol (EUG, phenylpropanoid of essential oils) has attracted attention due to its anti-inflammatory properties, as well as antioxidant effect.
On the other hand, it is volatile and insoluble and is a skin irritant.
In this case, nanostructured systems have been successfully employed as a drug carrier for skin diseases since they improve both biological and pharmaceutical properties of active compounds.
The cytotoxic, antioxidant, and anti-inflammatory effects of EUG were assessed in human neutrophils and keratinocytes.
Additionally, polymeric nanocarries (NCEUG) were prepared to improve the chemical and irritant characteristics of EUG.
EUG presented apparent safety and antioxidant and anti-inflammatory effects on human neutrophils, but presented cytotoxic effects on keratinocytes.
However, the nanocapsules were able to reduce its cytotoxicity.
An in vivo experiment of irritant contact dermatitis (ICD) in mice induced by TPA showed that NCEUG reduced significantly the ear edema in mice when compared to the EUG solution, as well as the leukocyte infiltration and IL-6 level, possibly due to better skin permeation and irritancy blockage.
These findings suggest that EUG is a promising bioactive molecule, and its nanoencapsulation seems to be an interesting approach for the treatment of ICD.
American Psychological Association (APA)
de Araújo Lopes, Amanda& da Fonseca, Francisco Noé& Rocha, Talita Magalhães& Freitas, Lyara Barbosa Nogueira & Araújo, Emmanuel Vinicius Oliveira& Wong, Deysi Viviana Tenazoa…[et al.]. 2018. Eugenol as a Promising Molecule for the Treatment of Dermatitis: Antioxidant and Anti-inflammatory Activities and Its Nanoformulation. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1212163
Modern Language Association (MLA)
de Araújo Lopes, Amanda…[et al.]. Eugenol as a Promising Molecule for the Treatment of Dermatitis: Antioxidant and Anti-inflammatory Activities and Its Nanoformulation. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1212163
American Medical Association (AMA)
de Araújo Lopes, Amanda& da Fonseca, Francisco Noé& Rocha, Talita Magalhães& Freitas, Lyara Barbosa Nogueira & Araújo, Emmanuel Vinicius Oliveira& Wong, Deysi Viviana Tenazoa…[et al.]. Eugenol as a Promising Molecule for the Treatment of Dermatitis: Antioxidant and Anti-inflammatory Activities and Its Nanoformulation. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1212163
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212163