Protective Effect of Rosamultin against H2O2-Induced Oxidative Stress and Apoptosis in H9c2 Cardiomyocytes
المؤلفون المشاركون
Li, Jianyu
Zhang, Yongliang
Li, Lingzhi
Zhang, Ling
Liu, Yang
Gong, Hai Ying
Cui, Ying
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-16
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Rosamultin is one of the main active compounds isolated from Potentilla anserina L., which belongs to a triterpene compound.
Few studies have examined the effect of rosamultin on oxidative stress and its molecular mechanism.
The aim of this present study was to elucidate the protective effect of rosamultin on H2O2-induced oxidative damage and apoptosis in H9c2 cardiomyocytes and its mechanism.
The results showed that the pretreatment of rosamultin not only increased cell viability but also reduced the release of LDH and CK.
Rosamultin inhibited a H2O2-induced decrease in SOD, CAT, and GSH-Px activities and an increase in MDA content.
Meanwhile, ROS level, intracellular (Ca2+) fluorescence intensity, and apoptosis rate in the rosamultin pretreated group were markedly decreased compared with the model group.
Rosamultin pretreatment significantly reversed the morphological changes and attenuated H2O2-induced apoptosis.
Western blot analysis showed that rosamultin enhanced the expression of Bcl-2 and pCryAB and downregulated the expression of Bax, Cyt-c, Caspase-3, and Caspase-9 expression.
Additionally, rosamultin might activate PI3K/Akt signal pathways and CryAB relative factors.
Therefore, we suggest that rosamultin could have the potential for treating H2O2-induced oxidative stress injury through its antioxidant and antiapoptosis effect.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Ling& Liu, Yang& Li, Jianyu& Li, Lingzhi& Zhang, Yongliang& Gong, Hai Ying…[et al.]. 2018. Protective Effect of Rosamultin against H2O2-Induced Oxidative Stress and Apoptosis in H9c2 Cardiomyocytes. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1212217
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Ling…[et al.]. Protective Effect of Rosamultin against H2O2-Induced Oxidative Stress and Apoptosis in H9c2 Cardiomyocytes. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1212217
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Ling& Liu, Yang& Li, Jianyu& Li, Lingzhi& Zhang, Yongliang& Gong, Hai Ying…[et al.]. Protective Effect of Rosamultin against H2O2-Induced Oxidative Stress and Apoptosis in H9c2 Cardiomyocytes. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1212217
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212217
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر