Cardiac Autonomic Neuropathy as a Result of Mild Hypercaloric Challenge in Absence of Signs of Diabetes: Modulation by Antidiabetic Drugs
المؤلفون المشاركون
Zouein, Fouad A.
Kaplan, Abdullah
Eid, Ali H.
Ghali, Rana
El-Yazbi, Ahmed
Al-Assi, Ola
Mroueh, Ali
Mougharbil, Nahed
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-31
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Cardiac autonomic neuropathy (CAN) is an early cardiovascular complication of diabetes occurring before metabolic derangement is evident.
The cause of CAN remains elusive and cannot be directly linked to hyperglycemia.
Recent clinical data report cardioprotective effects of some antidiabetic drugs independent of their hypoglycemic action.
Here, we used a rat model receiving limited daily increase in calories from fat (HC diet) to assess whether mild metabolic challenge led to CAN in absence of interfering effects of hyperglycemia, glucose intolerance, or obesity.
Rats receiving HC diet for 12 weeks showed reduction in baroreceptor sensitivity and heart rate variability despite lack of change in baseline hemodynamic and cardiovascular structural parameters.
Impairment of cardiac autonomic control was accompanied with perivascular adipose inflammation observed as an increased inflammatory cytokine expression, together with increased cardiac oxidative stress, and signaling derangement characteristic of diabetic cardiomyopathy.
Two-week treatment with metformin or pioglitazone rectified the autonomic derangement and corrected the molecular changes.
Switching rats to normal chow but not to isocaloric amounts of HC for two weeks reversed CAN.
As such, we conclude that adipose inflammation due to increased fat intake might underlie development of CAN and, hence, the beneficial effects of metformin and pioglitazone.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Al-Assi, Ola& Ghali, Rana& Mroueh, Ali& Kaplan, Abdullah& Mougharbil, Nahed& Eid, Ali H.…[et al.]. 2018. Cardiac Autonomic Neuropathy as a Result of Mild Hypercaloric Challenge in Absence of Signs of Diabetes: Modulation by Antidiabetic Drugs. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-19.
https://search.emarefa.net/detail/BIM-1212374
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Al-Assi, Ola…[et al.]. Cardiac Autonomic Neuropathy as a Result of Mild Hypercaloric Challenge in Absence of Signs of Diabetes: Modulation by Antidiabetic Drugs. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-19.
https://search.emarefa.net/detail/BIM-1212374
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Al-Assi, Ola& Ghali, Rana& Mroueh, Ali& Kaplan, Abdullah& Mougharbil, Nahed& Eid, Ali H.…[et al.]. Cardiac Autonomic Neuropathy as a Result of Mild Hypercaloric Challenge in Absence of Signs of Diabetes: Modulation by Antidiabetic Drugs. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-19.
https://search.emarefa.net/detail/BIM-1212374
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212374
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر