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Cardiac Autonomic Neuropathy as a Result of Mild Hypercaloric Challenge in Absence of Signs of Diabetes: Modulation by Antidiabetic Drugs
Joint Authors
Zouein, Fouad A.
Kaplan, Abdullah
Eid, Ali H.
Ghali, Rana
El-Yazbi, Ahmed
Al-Assi, Ola
Mroueh, Ali
Mougharbil, Nahed
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-31
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Cardiac autonomic neuropathy (CAN) is an early cardiovascular complication of diabetes occurring before metabolic derangement is evident.
The cause of CAN remains elusive and cannot be directly linked to hyperglycemia.
Recent clinical data report cardioprotective effects of some antidiabetic drugs independent of their hypoglycemic action.
Here, we used a rat model receiving limited daily increase in calories from fat (HC diet) to assess whether mild metabolic challenge led to CAN in absence of interfering effects of hyperglycemia, glucose intolerance, or obesity.
Rats receiving HC diet for 12 weeks showed reduction in baroreceptor sensitivity and heart rate variability despite lack of change in baseline hemodynamic and cardiovascular structural parameters.
Impairment of cardiac autonomic control was accompanied with perivascular adipose inflammation observed as an increased inflammatory cytokine expression, together with increased cardiac oxidative stress, and signaling derangement characteristic of diabetic cardiomyopathy.
Two-week treatment with metformin or pioglitazone rectified the autonomic derangement and corrected the molecular changes.
Switching rats to normal chow but not to isocaloric amounts of HC for two weeks reversed CAN.
As such, we conclude that adipose inflammation due to increased fat intake might underlie development of CAN and, hence, the beneficial effects of metformin and pioglitazone.
American Psychological Association (APA)
Al-Assi, Ola& Ghali, Rana& Mroueh, Ali& Kaplan, Abdullah& Mougharbil, Nahed& Eid, Ali H.…[et al.]. 2018. Cardiac Autonomic Neuropathy as a Result of Mild Hypercaloric Challenge in Absence of Signs of Diabetes: Modulation by Antidiabetic Drugs. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-19.
https://search.emarefa.net/detail/BIM-1212374
Modern Language Association (MLA)
Al-Assi, Ola…[et al.]. Cardiac Autonomic Neuropathy as a Result of Mild Hypercaloric Challenge in Absence of Signs of Diabetes: Modulation by Antidiabetic Drugs. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-19.
https://search.emarefa.net/detail/BIM-1212374
American Medical Association (AMA)
Al-Assi, Ola& Ghali, Rana& Mroueh, Ali& Kaplan, Abdullah& Mougharbil, Nahed& Eid, Ali H.…[et al.]. Cardiac Autonomic Neuropathy as a Result of Mild Hypercaloric Challenge in Absence of Signs of Diabetes: Modulation by Antidiabetic Drugs. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-19.
https://search.emarefa.net/detail/BIM-1212374
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212374