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Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROSMAPK and TLR4NF-κB Signaling Pathways
المؤلفون المشاركون
Wu, Dongdong
Ji, Xinying
Wei, Jianshe
Li, Tao
Wang, Da-Yong
Duan, Shao-Feng
Zhang, Guo-Yu
Lu, Dan
Gao, Ying-Ran
Liu, Shi-Yu
Hong, Ya
Dong, Peng-Zhen
Chen, Ya-Ge
Cheng, Xiang-Shu
He, Fei
Li, Guang-Yu
Zhang, Qing-Yong
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-24
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Diaphragm dysfunction is an important clinical problem worldwide.
Hydrogen sulfide (H2S) is involved in many physiological and pathological processes in mammals.
However, the effect and mechanism of H2S in diaphragm dysfunction have not been fully elucidated.
In this study, we detected that the level of H2S was decreased in lipopolysaccharide- (LPS-) treated L6 cells.
Treatment with H2S increased the proliferation and viability of LPS-treated L6 cells.
We found that H2S decreased reactive oxygen species- (ROS-) induced apoptosis through the mitogen-activated protein kinase (MAPK) signaling pathway in LPS-treated L6 cells.
Administration of H2S alleviated LPS-induced inflammation by mediating the toll-like receptor-4 (TLR-4)/nuclear factor-kappa B (NF-κB) signaling pathway in L6 cells.
Furthermore, H2S improved diaphragmatic function and structure through the reduction of inflammation and apoptosis in the diaphragm of septic rats.
In conclusion, these findings indicate that H2S ameliorates LPS-induced diaphragm dysfunction in rats by reducing apoptosis and inflammation through ROS/MAPK and TLR4/NF-κB signaling pathways.
Novel slow-releasing H2S donors can be designed and applied for the treatment of diaphragm dysfunction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Guo-Yu& Lu, Dan& Duan, Shao-Feng& Gao, Ying-Ran& Liu, Shi-Yu& Hong, Ya…[et al.]. 2018. Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROSMAPK and TLR4NF-κB Signaling Pathways. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1212397
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Guo-Yu…[et al.]. Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROSMAPK and TLR4NF-κB Signaling Pathways. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1212397
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Guo-Yu& Lu, Dan& Duan, Shao-Feng& Gao, Ying-Ran& Liu, Shi-Yu& Hong, Ya…[et al.]. Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROSMAPK and TLR4NF-κB Signaling Pathways. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1212397
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212397
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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