Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROSMAPK and TLR4NF-κB Signaling Pathways
Joint Authors
Wu, Dongdong
Ji, Xinying
Wei, Jianshe
Li, Tao
Wang, Da-Yong
Duan, Shao-Feng
Zhang, Guo-Yu
Lu, Dan
Gao, Ying-Ran
Liu, Shi-Yu
Hong, Ya
Dong, Peng-Zhen
Chen, Ya-Ge
Cheng, Xiang-Shu
He, Fei
Li, Guang-Yu
Zhang, Qing-Yong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-24
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Diaphragm dysfunction is an important clinical problem worldwide.
Hydrogen sulfide (H2S) is involved in many physiological and pathological processes in mammals.
However, the effect and mechanism of H2S in diaphragm dysfunction have not been fully elucidated.
In this study, we detected that the level of H2S was decreased in lipopolysaccharide- (LPS-) treated L6 cells.
Treatment with H2S increased the proliferation and viability of LPS-treated L6 cells.
We found that H2S decreased reactive oxygen species- (ROS-) induced apoptosis through the mitogen-activated protein kinase (MAPK) signaling pathway in LPS-treated L6 cells.
Administration of H2S alleviated LPS-induced inflammation by mediating the toll-like receptor-4 (TLR-4)/nuclear factor-kappa B (NF-κB) signaling pathway in L6 cells.
Furthermore, H2S improved diaphragmatic function and structure through the reduction of inflammation and apoptosis in the diaphragm of septic rats.
In conclusion, these findings indicate that H2S ameliorates LPS-induced diaphragm dysfunction in rats by reducing apoptosis and inflammation through ROS/MAPK and TLR4/NF-κB signaling pathways.
Novel slow-releasing H2S donors can be designed and applied for the treatment of diaphragm dysfunction.
American Psychological Association (APA)
Zhang, Guo-Yu& Lu, Dan& Duan, Shao-Feng& Gao, Ying-Ran& Liu, Shi-Yu& Hong, Ya…[et al.]. 2018. Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROSMAPK and TLR4NF-κB Signaling Pathways. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1212397
Modern Language Association (MLA)
Zhang, Guo-Yu…[et al.]. Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROSMAPK and TLR4NF-κB Signaling Pathways. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1212397
American Medical Association (AMA)
Zhang, Guo-Yu& Lu, Dan& Duan, Shao-Feng& Gao, Ying-Ran& Liu, Shi-Yu& Hong, Ya…[et al.]. Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROSMAPK and TLR4NF-κB Signaling Pathways. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1212397
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212397