![](/images/graphics-bg.png)
Oxidized DJ-1 Levels in Urine Samples as a Putative Biomarker for Parkinson’s Disease
المؤلفون المشاركون
Seo, Hyemyung
Son, Ilhong
Seol, Wongi
Ho, Dong Hwan
Jang, Jihoon
Lee, Sung Ik
Jeong, Soyeon
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-14
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Parkinson’s disease (PD) is the second most common neurodegenerative disease.
Oxidative stress is the most critical risk factor for neurodegenerative diseases, including Alzheimer’s disease (AD) and Huntington’s disease (HD).
Numerous reports have demonstrated that oxidative stress aggravates cytotoxicity in dopaminergic neurons and accelerates the formation of protein inclusions.
In addition, oxidative stress, such as 4-hydroxynonenal (HNE), oxidized protein, and dopamine quinone, are related to PD progression.
DJ-1 is a PD-causative gene, and it plays a pivotal role as a sensor and eliminator of oxidative stress.
Several studies have shown that oxidized DJ-1 (OxiDJ-1) formation is induced by oxidative stress.
Hence, previous studies suggest that oxidized DJ-1 could be a biomarker for PD.
We previously reported higher DJ-1 levels in Korean male PD patient urine exosomes than male non-PD controls.
We speculate that OxiDJ-1 levels in PD patient urine might be higher than that in non-PD controls.
In this study, we established an ELISA for OxiDJ-1 using recombinant DJ-1 treated with H2O2.
Using Western blot assay and ELISA, we confirmed an increase of OxiDJ-1 from HEK293T cells treated with H2O2.
Using our ELISA, we observed significantly higher, 2-fold, OxiDJ-1 levels in the urine of Korean PD patients than in non-PD controls.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jang, Jihoon& Jeong, Soyeon& Lee, Sung Ik& Seol, Wongi& Seo, Hyemyung& Son, Ilhong…[et al.]. 2018. Oxidized DJ-1 Levels in Urine Samples as a Putative Biomarker for Parkinson’s Disease. Parkinson’s Disease،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1212443
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jang, Jihoon…[et al.]. Oxidized DJ-1 Levels in Urine Samples as a Putative Biomarker for Parkinson’s Disease. Parkinson’s Disease No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1212443
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jang, Jihoon& Jeong, Soyeon& Lee, Sung Ik& Seol, Wongi& Seo, Hyemyung& Son, Ilhong…[et al.]. Oxidized DJ-1 Levels in Urine Samples as a Putative Biomarker for Parkinson’s Disease. Parkinson’s Disease. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1212443
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212443
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)