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The Contribution of Endogenous Modulatory Systems to TMS- and tDCS-Induced Analgesia: Evidence from PET Studies
المؤلفون المشاركون
Ferreira, Natália R.
Rosado-de-Castro, Paulo Henrique
DosSantos, Marcos Fabio
Oliveira, Aleli Tôrres
Carvalho, Antonio Carlos Pires
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-13
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Chronic pain is an important public health issue.
Moreover, its adequate management is still considered a major clinical problem, mainly due to its incredible complexity and still poorly understood pathophysiology.
Recent scientific evidence coming from neuroimaging research, particularly functional magnetic resonance (fMRI) and positron emission tomography (PET) studies, indicates that chronic pain is associated with structural and functional changes in several brain structures that integrate antinociceptive pathways and endogenous modulatory systems.
Furthermore, the last two decades have witnessed a huge increase in the number of studies evaluating the clinical effects of noninvasive neuromodulatory methods, especially transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), which have been proved to effectively modulate the cortical excitability, resulting in satisfactory analgesic effects with minimal adverse events.
Nevertheless, the precise neuromechanisms whereby such methods provide pain control are still largely unexplored.
Recent studies have brought valuable information regarding the recruitment of different modulatory systems and related neurotransmitters, including glutamate, dopamine, and endogenous opioids.
However, the specific neurocircuits involved in the analgesia produced by those therapies have not been fully elucidated.
This review focuses on the current literature correlating the clinical effects of noninvasive methods of brain stimulation to the changes in the activity of endogenous modulatory systems.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
DosSantos, Marcos Fabio& Oliveira, Aleli Tôrres& Ferreira, Natália R.& Carvalho, Antonio Carlos Pires& Rosado-de-Castro, Paulo Henrique. 2018. The Contribution of Endogenous Modulatory Systems to TMS- and tDCS-Induced Analgesia: Evidence from PET Studies. Pain Research and Management،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1212542
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
DosSantos, Marcos Fabio…[et al.]. The Contribution of Endogenous Modulatory Systems to TMS- and tDCS-Induced Analgesia: Evidence from PET Studies. Pain Research and Management No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1212542
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
DosSantos, Marcos Fabio& Oliveira, Aleli Tôrres& Ferreira, Natália R.& Carvalho, Antonio Carlos Pires& Rosado-de-Castro, Paulo Henrique. The Contribution of Endogenous Modulatory Systems to TMS- and tDCS-Induced Analgesia: Evidence from PET Studies. Pain Research and Management. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1212542
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212542
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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