The Contribution of Endogenous Modulatory Systems to TMS- and tDCS-Induced Analgesia: Evidence from PET Studies
Joint Authors
Ferreira, Natália R.
Rosado-de-Castro, Paulo Henrique
DosSantos, Marcos Fabio
Oliveira, Aleli Tôrres
Carvalho, Antonio Carlos Pires
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-13
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Chronic pain is an important public health issue.
Moreover, its adequate management is still considered a major clinical problem, mainly due to its incredible complexity and still poorly understood pathophysiology.
Recent scientific evidence coming from neuroimaging research, particularly functional magnetic resonance (fMRI) and positron emission tomography (PET) studies, indicates that chronic pain is associated with structural and functional changes in several brain structures that integrate antinociceptive pathways and endogenous modulatory systems.
Furthermore, the last two decades have witnessed a huge increase in the number of studies evaluating the clinical effects of noninvasive neuromodulatory methods, especially transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), which have been proved to effectively modulate the cortical excitability, resulting in satisfactory analgesic effects with minimal adverse events.
Nevertheless, the precise neuromechanisms whereby such methods provide pain control are still largely unexplored.
Recent studies have brought valuable information regarding the recruitment of different modulatory systems and related neurotransmitters, including glutamate, dopamine, and endogenous opioids.
However, the specific neurocircuits involved in the analgesia produced by those therapies have not been fully elucidated.
This review focuses on the current literature correlating the clinical effects of noninvasive methods of brain stimulation to the changes in the activity of endogenous modulatory systems.
American Psychological Association (APA)
DosSantos, Marcos Fabio& Oliveira, Aleli Tôrres& Ferreira, Natália R.& Carvalho, Antonio Carlos Pires& Rosado-de-Castro, Paulo Henrique. 2018. The Contribution of Endogenous Modulatory Systems to TMS- and tDCS-Induced Analgesia: Evidence from PET Studies. Pain Research and Management،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1212542
Modern Language Association (MLA)
DosSantos, Marcos Fabio…[et al.]. The Contribution of Endogenous Modulatory Systems to TMS- and tDCS-Induced Analgesia: Evidence from PET Studies. Pain Research and Management No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1212542
American Medical Association (AMA)
DosSantos, Marcos Fabio& Oliveira, Aleli Tôrres& Ferreira, Natália R.& Carvalho, Antonio Carlos Pires& Rosado-de-Castro, Paulo Henrique. The Contribution of Endogenous Modulatory Systems to TMS- and tDCS-Induced Analgesia: Evidence from PET Studies. Pain Research and Management. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1212542
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212542