Neuropilin 1 Mediates Keratinocyte Growth Factor Signaling in Adipose-Derived Stem Cells: Potential Involvement in Adipogenesis
المؤلفون المشاركون
Nodale, Cristina
Ceccarelli, Simona
Angeloni, Antonio
Sorice, Maurizio
Manganelli, Valeria
Onesti, Maria Giuseppina
Vescarelli, Enrica
Pontecorvi, Paola
Casella, Giovanni
Romano, Ferdinando
Marchese, Cinzia
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-25
دولة النشر
مصر
عدد الصفحات
18
الملخص EN
Adipogenesis is regulated by a complex network of molecules, including fibroblast growth factors.
Keratinocyte growth factor (KGF) has been previously reported to promote proliferation on rat preadipocytes, although the expression of its specific receptor, FGFR2-IIIb/KGFR, is not actually detected in mesenchymal cells.
Here, we demonstrate that human adipose-derived stem cells (ASCs) show increased expression of KGF during adipogenic differentiation, especially in the early steps.
Moreover, KGF is able to induce transient activation of ERK and p38 MAPK pathways in these cells.
Furthermore, KGF promotes ASC differentiation and supports the activation of differentiation pathways, such as those of PI3K/Akt and the retinoblastoma protein (Rb).
Notably, we observed only a low amount of FGFR2-IIIb in ASCs, which seems not to be responsible for KGF activity.
Here, we demonstrate for the first time that Neuropilin 1 (NRP1), a transmembrane glycoprotein expressed in ASCs acting as a coreceptor for some growth factors, is responsible for KGF-dependent pathway activation in these cells.
Our study contributes to clarify the molecular bases of human adipogenesis, demonstrating a role of KGF in the early steps of this process, and points out a role of NRP1 as a previously unknown mediator of KGF action in ASCs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ceccarelli, Simona& Nodale, Cristina& Vescarelli, Enrica& Pontecorvi, Paola& Manganelli, Valeria& Casella, Giovanni…[et al.]. 2018. Neuropilin 1 Mediates Keratinocyte Growth Factor Signaling in Adipose-Derived Stem Cells: Potential Involvement in Adipogenesis. Stem Cells International،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1213088
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ceccarelli, Simona…[et al.]. Neuropilin 1 Mediates Keratinocyte Growth Factor Signaling in Adipose-Derived Stem Cells: Potential Involvement in Adipogenesis. Stem Cells International No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1213088
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ceccarelli, Simona& Nodale, Cristina& Vescarelli, Enrica& Pontecorvi, Paola& Manganelli, Valeria& Casella, Giovanni…[et al.]. Neuropilin 1 Mediates Keratinocyte Growth Factor Signaling in Adipose-Derived Stem Cells: Potential Involvement in Adipogenesis. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1213088
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1213088
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر