Neuropilin 1 Mediates Keratinocyte Growth Factor Signaling in Adipose-Derived Stem Cells: Potential Involvement in Adipogenesis
Joint Authors
Nodale, Cristina
Ceccarelli, Simona
Angeloni, Antonio
Sorice, Maurizio
Manganelli, Valeria
Onesti, Maria Giuseppina
Vescarelli, Enrica
Pontecorvi, Paola
Casella, Giovanni
Romano, Ferdinando
Marchese, Cinzia
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-25
Country of Publication
Egypt
No. of Pages
18
Abstract EN
Adipogenesis is regulated by a complex network of molecules, including fibroblast growth factors.
Keratinocyte growth factor (KGF) has been previously reported to promote proliferation on rat preadipocytes, although the expression of its specific receptor, FGFR2-IIIb/KGFR, is not actually detected in mesenchymal cells.
Here, we demonstrate that human adipose-derived stem cells (ASCs) show increased expression of KGF during adipogenic differentiation, especially in the early steps.
Moreover, KGF is able to induce transient activation of ERK and p38 MAPK pathways in these cells.
Furthermore, KGF promotes ASC differentiation and supports the activation of differentiation pathways, such as those of PI3K/Akt and the retinoblastoma protein (Rb).
Notably, we observed only a low amount of FGFR2-IIIb in ASCs, which seems not to be responsible for KGF activity.
Here, we demonstrate for the first time that Neuropilin 1 (NRP1), a transmembrane glycoprotein expressed in ASCs acting as a coreceptor for some growth factors, is responsible for KGF-dependent pathway activation in these cells.
Our study contributes to clarify the molecular bases of human adipogenesis, demonstrating a role of KGF in the early steps of this process, and points out a role of NRP1 as a previously unknown mediator of KGF action in ASCs.
American Psychological Association (APA)
Ceccarelli, Simona& Nodale, Cristina& Vescarelli, Enrica& Pontecorvi, Paola& Manganelli, Valeria& Casella, Giovanni…[et al.]. 2018. Neuropilin 1 Mediates Keratinocyte Growth Factor Signaling in Adipose-Derived Stem Cells: Potential Involvement in Adipogenesis. Stem Cells International،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1213088
Modern Language Association (MLA)
Ceccarelli, Simona…[et al.]. Neuropilin 1 Mediates Keratinocyte Growth Factor Signaling in Adipose-Derived Stem Cells: Potential Involvement in Adipogenesis. Stem Cells International No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1213088
American Medical Association (AMA)
Ceccarelli, Simona& Nodale, Cristina& Vescarelli, Enrica& Pontecorvi, Paola& Manganelli, Valeria& Casella, Giovanni…[et al.]. Neuropilin 1 Mediates Keratinocyte Growth Factor Signaling in Adipose-Derived Stem Cells: Potential Involvement in Adipogenesis. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1213088
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213088