Amniotic Epithelial Cells Accelerate Diabetic Wound Healing by Modulating Inflammation and Promoting Neovascularization
المؤلفون المشاركون
Xia, Zhao-fan
Liu, Yu-huan
Zheng, Yongjun
Zheng, Shiqing
Fan, Xiaoming
Li, Li
Xiao, Yongqiang
Luo, Pengfei
Liu, Yingying
Wang, Li
Cui, Zhenci
He, Fei
Xiao, Shichu
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-19
دولة النشر
مصر
عدد الصفحات
10
الملخص EN
Human amniotic epithelial cells (hAECs) are nontumorigenic, highly abundant, and low immunogenic and possess multipotent differentiation ability, which make them become ideal alternative stem cell source for regenerative medicine.
Previous studies have demonstrated the therapeutic potential of hAECs in many tissue repairs.
However, the therapeutic effect of hAECs on diabetic wound healing is still unknown.
In this study, we injected hAECs intradermally around the full-thickness excisional skin wounds of db/db mice and found that hAECs significantly accelerated diabetic wound healing and granulation tissue formation.
To explore the underlying mechanisms, we measured inflammation and neovascularization in diabetic wounds.
hAECs could modulate macrophage phenotype toward M2 macrophage, promote switch from proinflammatory status to prohealing status of wounds, and increase capillary density in diabetic wounds.
Furthermore, we found that the hAEC-conditioned medium promoted macrophage polarization toward M2 phenotype and facilitated migration, proliferation, and tube formation of endothelial cells through in vitro experiments.
Taken together, we first reported that hAECs could promote diabetic wound healing, at least partially, through paracrine effects to regulate inflammation and promote neovascularization.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zheng, Yongjun& Zheng, Shiqing& Fan, Xiaoming& Li, Li& Xiao, Yongqiang& Luo, Pengfei…[et al.]. 2018. Amniotic Epithelial Cells Accelerate Diabetic Wound Healing by Modulating Inflammation and Promoting Neovascularization. Stem Cells International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213092
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zheng, Yongjun…[et al.]. Amniotic Epithelial Cells Accelerate Diabetic Wound Healing by Modulating Inflammation and Promoting Neovascularization. Stem Cells International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1213092
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zheng, Yongjun& Zheng, Shiqing& Fan, Xiaoming& Li, Li& Xiao, Yongqiang& Luo, Pengfei…[et al.]. Amniotic Epithelial Cells Accelerate Diabetic Wound Healing by Modulating Inflammation and Promoting Neovascularization. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213092
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1213092
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر