Amniotic Epithelial Cells Accelerate Diabetic Wound Healing by Modulating Inflammation and Promoting Neovascularization
Joint Authors
Xia, Zhao-fan
Liu, Yu-huan
Zheng, Yongjun
Zheng, Shiqing
Fan, Xiaoming
Li, Li
Xiao, Yongqiang
Luo, Pengfei
Liu, Yingying
Wang, Li
Cui, Zhenci
He, Fei
Xiao, Shichu
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-19
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Human amniotic epithelial cells (hAECs) are nontumorigenic, highly abundant, and low immunogenic and possess multipotent differentiation ability, which make them become ideal alternative stem cell source for regenerative medicine.
Previous studies have demonstrated the therapeutic potential of hAECs in many tissue repairs.
However, the therapeutic effect of hAECs on diabetic wound healing is still unknown.
In this study, we injected hAECs intradermally around the full-thickness excisional skin wounds of db/db mice and found that hAECs significantly accelerated diabetic wound healing and granulation tissue formation.
To explore the underlying mechanisms, we measured inflammation and neovascularization in diabetic wounds.
hAECs could modulate macrophage phenotype toward M2 macrophage, promote switch from proinflammatory status to prohealing status of wounds, and increase capillary density in diabetic wounds.
Furthermore, we found that the hAEC-conditioned medium promoted macrophage polarization toward M2 phenotype and facilitated migration, proliferation, and tube formation of endothelial cells through in vitro experiments.
Taken together, we first reported that hAECs could promote diabetic wound healing, at least partially, through paracrine effects to regulate inflammation and promote neovascularization.
American Psychological Association (APA)
Zheng, Yongjun& Zheng, Shiqing& Fan, Xiaoming& Li, Li& Xiao, Yongqiang& Luo, Pengfei…[et al.]. 2018. Amniotic Epithelial Cells Accelerate Diabetic Wound Healing by Modulating Inflammation and Promoting Neovascularization. Stem Cells International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213092
Modern Language Association (MLA)
Zheng, Yongjun…[et al.]. Amniotic Epithelial Cells Accelerate Diabetic Wound Healing by Modulating Inflammation and Promoting Neovascularization. Stem Cells International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1213092
American Medical Association (AMA)
Zheng, Yongjun& Zheng, Shiqing& Fan, Xiaoming& Li, Li& Xiao, Yongqiang& Luo, Pengfei…[et al.]. Amniotic Epithelial Cells Accelerate Diabetic Wound Healing by Modulating Inflammation and Promoting Neovascularization. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213092
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213092