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Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Optimal Monitoring Tools
المؤلفون المشاركون
Sarnowska, Anna
Figiel-Dabrowska, Anna
Noszczyk, Bartlomiej Henryk
Domanska-Janik, Krystyna
Krzesniak, Natalia
Kuzma-Kozakiewicz, Magdalena
Marchel, Andrzej
Kaminska, Anna
Gawel, Malgorzata
Sznajder, Jan
Nowak, Arkadiusz
Maj, Edyta
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-12
دولة النشر
مصر
عدد الصفحات
16
الملخص EN
Stem cells (SCs) may constitute a perspective alternative to pharmacological treatment in neurodegenerative diseases.
Although the safety of SC transplantation has been widely shown, their clinical efficiency in amyotrophic lateral sclerosis (ALS) is still to be proved.
It is not only due to a limited number of studies, small treatment groups, and fast but nonlinear disease progression but also due to lack of objective methods able to show subtle clinical changes.
Preliminary guidelines for cell therapy have recently been proposed by a group of ALS experts.
They combine clinical, neurophysiological, and functional assessment together with monitoring of the cytokine level.
Here, we describe a pilot study on transplantation of autologous adipose-derived regenerative cells (ADRC) into the spinal cord of the patients with ALS and monitoring of the results in accordance with the current recommendations.
To show early and/or subtle changes within the muscles of interest, a wide range of clinical and functional tests were used and compared in order to choose the most sensitive and optimal set.
Additionally, an analysis of transplanted ADRC was provided to develop standards ensuring the derivation and verification of adequate quality of transplanted cells and to correlate ADRC properties with clinical outcome.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kuzma-Kozakiewicz, Magdalena& Marchel, Andrzej& Kaminska, Anna& Gawel, Malgorzata& Sznajder, Jan& Figiel-Dabrowska, Anna…[et al.]. 2018. Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Optimal Monitoring Tools. Stem Cells International،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1213401
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kuzma-Kozakiewicz, Magdalena…[et al.]. Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Optimal Monitoring Tools. Stem Cells International No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1213401
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kuzma-Kozakiewicz, Magdalena& Marchel, Andrzej& Kaminska, Anna& Gawel, Malgorzata& Sznajder, Jan& Figiel-Dabrowska, Anna…[et al.]. Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Optimal Monitoring Tools. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1213401
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1213401
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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