![](/images/graphics-bg.png)
Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Optimal Monitoring Tools
Joint Authors
Sarnowska, Anna
Figiel-Dabrowska, Anna
Noszczyk, Bartlomiej Henryk
Domanska-Janik, Krystyna
Krzesniak, Natalia
Kuzma-Kozakiewicz, Magdalena
Marchel, Andrzej
Kaminska, Anna
Gawel, Malgorzata
Sznajder, Jan
Nowak, Arkadiusz
Maj, Edyta
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-12
Country of Publication
Egypt
No. of Pages
16
Abstract EN
Stem cells (SCs) may constitute a perspective alternative to pharmacological treatment in neurodegenerative diseases.
Although the safety of SC transplantation has been widely shown, their clinical efficiency in amyotrophic lateral sclerosis (ALS) is still to be proved.
It is not only due to a limited number of studies, small treatment groups, and fast but nonlinear disease progression but also due to lack of objective methods able to show subtle clinical changes.
Preliminary guidelines for cell therapy have recently been proposed by a group of ALS experts.
They combine clinical, neurophysiological, and functional assessment together with monitoring of the cytokine level.
Here, we describe a pilot study on transplantation of autologous adipose-derived regenerative cells (ADRC) into the spinal cord of the patients with ALS and monitoring of the results in accordance with the current recommendations.
To show early and/or subtle changes within the muscles of interest, a wide range of clinical and functional tests were used and compared in order to choose the most sensitive and optimal set.
Additionally, an analysis of transplanted ADRC was provided to develop standards ensuring the derivation and verification of adequate quality of transplanted cells and to correlate ADRC properties with clinical outcome.
American Psychological Association (APA)
Kuzma-Kozakiewicz, Magdalena& Marchel, Andrzej& Kaminska, Anna& Gawel, Malgorzata& Sznajder, Jan& Figiel-Dabrowska, Anna…[et al.]. 2018. Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Optimal Monitoring Tools. Stem Cells International،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1213401
Modern Language Association (MLA)
Kuzma-Kozakiewicz, Magdalena…[et al.]. Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Optimal Monitoring Tools. Stem Cells International No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1213401
American Medical Association (AMA)
Kuzma-Kozakiewicz, Magdalena& Marchel, Andrzej& Kaminska, Anna& Gawel, Malgorzata& Sznajder, Jan& Figiel-Dabrowska, Anna…[et al.]. Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Optimal Monitoring Tools. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1213401
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213401