Neural Stem Cell-Conditioned Medium Ameliorated Cerebral Ischemia-Reperfusion Injury in Rats

المؤلفون المشاركون

Wang, Hao
Yang, HongNa
Wang, Cuilan
Chen, Hui
Li, Lan
Ma, Shuang
Fu, YaRu
Qu, Tingyu

المصدر

Stem Cells International

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-04-03

دولة النشر

مصر

عدد الصفحات

7

الملخص EN

Introduction.

Our previous study suggested that NSC-CM (neural stem cell-conditioned medium) inhibited cell apoptosis in vitro.

In addition, many studies have shown that neurotrophic factors and microparticles secreted into a conditioned medium by NSCs had neuroprotective effects.

Thus, we hypothesized that NSC-CM had the capacity of protecting against cerebral I/R injury.

Methods.

Adult male Sprague-Dawley rats receiving middle cerebral artery occlusion surgery as an animal model of cerebral I/R injury were randomly assigned to two groups: the control group and NSC-CM-treated group.

1.5 ml NSC-CM or PBS (phosphate buffer saline) was administrated slowly by tail vein at 3 h, 24 h, and 48 h after ischemia onset.

Results.

NSC-CM significantly ameliorated neurological defects and reduced cerebral infarct volume, accompanied by preserved mitochondrial ultrastructure.

In addition, we also found that NSC-CM significantly inhibited cell apoptosis in the ischemic hemisphere via improving the expression of Bcl-2 (B-cell lymphoma-2).

Conclusion.

NSC-CM might be an alternative and effective therapeutic intervention for ischemic stroke.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Yang, HongNa& Wang, Cuilan& Chen, Hui& Li, Lan& Ma, Shuang& Wang, Hao…[et al.]. 2018. Neural Stem Cell-Conditioned Medium Ameliorated Cerebral Ischemia-Reperfusion Injury in Rats. Stem Cells International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1213407

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Yang, HongNa…[et al.]. Neural Stem Cell-Conditioned Medium Ameliorated Cerebral Ischemia-Reperfusion Injury in Rats. Stem Cells International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1213407

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Yang, HongNa& Wang, Cuilan& Chen, Hui& Li, Lan& Ma, Shuang& Wang, Hao…[et al.]. Neural Stem Cell-Conditioned Medium Ameliorated Cerebral Ischemia-Reperfusion Injury in Rats. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1213407

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1213407