Neural Stem Cell-Conditioned Medium Ameliorated Cerebral Ischemia-Reperfusion Injury in Rats
Joint Authors
Wang, Hao
Yang, HongNa
Wang, Cuilan
Chen, Hui
Li, Lan
Ma, Shuang
Fu, YaRu
Qu, Tingyu
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-03
Country of Publication
Egypt
No. of Pages
7
Abstract EN
Introduction.
Our previous study suggested that NSC-CM (neural stem cell-conditioned medium) inhibited cell apoptosis in vitro.
In addition, many studies have shown that neurotrophic factors and microparticles secreted into a conditioned medium by NSCs had neuroprotective effects.
Thus, we hypothesized that NSC-CM had the capacity of protecting against cerebral I/R injury.
Methods.
Adult male Sprague-Dawley rats receiving middle cerebral artery occlusion surgery as an animal model of cerebral I/R injury were randomly assigned to two groups: the control group and NSC-CM-treated group.
1.5 ml NSC-CM or PBS (phosphate buffer saline) was administrated slowly by tail vein at 3 h, 24 h, and 48 h after ischemia onset.
Results.
NSC-CM significantly ameliorated neurological defects and reduced cerebral infarct volume, accompanied by preserved mitochondrial ultrastructure.
In addition, we also found that NSC-CM significantly inhibited cell apoptosis in the ischemic hemisphere via improving the expression of Bcl-2 (B-cell lymphoma-2).
Conclusion.
NSC-CM might be an alternative and effective therapeutic intervention for ischemic stroke.
American Psychological Association (APA)
Yang, HongNa& Wang, Cuilan& Chen, Hui& Li, Lan& Ma, Shuang& Wang, Hao…[et al.]. 2018. Neural Stem Cell-Conditioned Medium Ameliorated Cerebral Ischemia-Reperfusion Injury in Rats. Stem Cells International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1213407
Modern Language Association (MLA)
Yang, HongNa…[et al.]. Neural Stem Cell-Conditioned Medium Ameliorated Cerebral Ischemia-Reperfusion Injury in Rats. Stem Cells International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1213407
American Medical Association (AMA)
Yang, HongNa& Wang, Cuilan& Chen, Hui& Li, Lan& Ma, Shuang& Wang, Hao…[et al.]. Neural Stem Cell-Conditioned Medium Ameliorated Cerebral Ischemia-Reperfusion Injury in Rats. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1213407
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213407