Knitted 3D Scaffolds of Polybutylene Succinate Support Human Mesenchymal Stem Cell Growth and Osteogenesis
المؤلفون المشاركون
Miettinen, Susanna
Ojansivu, Miina
Vanhatupa, Sari
Johansson, Laura
Tamminen, Ilmari
Hannula, Markus
Kellomäki, Minna
Hyttinen, Jari
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-07
دولة النشر
مصر
عدد الصفحات
11
الملخص EN
Polybutylene succinate (PBS) is a biodegradable polyester with better processability and different mechanical properties compared to polylactides (PLAs), the most commonly used synthetic polymers in tissue engineering (TE).
Since only few studies have evaluated PBS-containing materials for bone TE, we prepared PLA-PBS blends and analyzed material properties as well as cell attachment, proliferation, and osteogenic differentiation of human mesenchymal stem cells (hMSCs) on scaffolds.
In addition to PLA, PBS, and PLA-PBS blends, PLA-polycaprolactone and PLA-poly(trimethylene carbonate) blends were evaluated.
Polymer fibers were prepared using melt spinning.
Pure PBS was observed to have the highest crystallinity and strain at break compared to the tougher PLA and PLA blends.
No degradation occurred during the 4-week hydrolysis in either of the materials.
Knitted and rolled scaffolds were manufactured, seeded with hMSCs, and cultured for 27 days.
Human MSC viability was good on all the materials, but cell spreading along the fibers was only detected in PBS-containing scaffolds.
They also induced the strongest proliferative response and osteogenic differentiation, which diminished with decreasing PBS content.
Based on these results, PBS is superior to PLA with respect to hMSC attachment, proliferation, and osteogenesis.
This encourages utilizing PBS-based biomaterials more widely in bone TE applications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ojansivu, Miina& Johansson, Laura& Vanhatupa, Sari& Tamminen, Ilmari& Hannula, Markus& Hyttinen, Jari…[et al.]. 2018. Knitted 3D Scaffolds of Polybutylene Succinate Support Human Mesenchymal Stem Cell Growth and Osteogenesis. Stem Cells International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1213489
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ojansivu, Miina…[et al.]. Knitted 3D Scaffolds of Polybutylene Succinate Support Human Mesenchymal Stem Cell Growth and Osteogenesis. Stem Cells International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1213489
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ojansivu, Miina& Johansson, Laura& Vanhatupa, Sari& Tamminen, Ilmari& Hannula, Markus& Hyttinen, Jari…[et al.]. Knitted 3D Scaffolds of Polybutylene Succinate Support Human Mesenchymal Stem Cell Growth and Osteogenesis. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1213489
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1213489
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر