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Knitted 3D Scaffolds of Polybutylene Succinate Support Human Mesenchymal Stem Cell Growth and Osteogenesis
Joint Authors
Miettinen, Susanna
Ojansivu, Miina
Vanhatupa, Sari
Johansson, Laura
Tamminen, Ilmari
Hannula, Markus
Kellomäki, Minna
Hyttinen, Jari
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-07
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Polybutylene succinate (PBS) is a biodegradable polyester with better processability and different mechanical properties compared to polylactides (PLAs), the most commonly used synthetic polymers in tissue engineering (TE).
Since only few studies have evaluated PBS-containing materials for bone TE, we prepared PLA-PBS blends and analyzed material properties as well as cell attachment, proliferation, and osteogenic differentiation of human mesenchymal stem cells (hMSCs) on scaffolds.
In addition to PLA, PBS, and PLA-PBS blends, PLA-polycaprolactone and PLA-poly(trimethylene carbonate) blends were evaluated.
Polymer fibers were prepared using melt spinning.
Pure PBS was observed to have the highest crystallinity and strain at break compared to the tougher PLA and PLA blends.
No degradation occurred during the 4-week hydrolysis in either of the materials.
Knitted and rolled scaffolds were manufactured, seeded with hMSCs, and cultured for 27 days.
Human MSC viability was good on all the materials, but cell spreading along the fibers was only detected in PBS-containing scaffolds.
They also induced the strongest proliferative response and osteogenic differentiation, which diminished with decreasing PBS content.
Based on these results, PBS is superior to PLA with respect to hMSC attachment, proliferation, and osteogenesis.
This encourages utilizing PBS-based biomaterials more widely in bone TE applications.
American Psychological Association (APA)
Ojansivu, Miina& Johansson, Laura& Vanhatupa, Sari& Tamminen, Ilmari& Hannula, Markus& Hyttinen, Jari…[et al.]. 2018. Knitted 3D Scaffolds of Polybutylene Succinate Support Human Mesenchymal Stem Cell Growth and Osteogenesis. Stem Cells International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1213489
Modern Language Association (MLA)
Ojansivu, Miina…[et al.]. Knitted 3D Scaffolds of Polybutylene Succinate Support Human Mesenchymal Stem Cell Growth and Osteogenesis. Stem Cells International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1213489
American Medical Association (AMA)
Ojansivu, Miina& Johansson, Laura& Vanhatupa, Sari& Tamminen, Ilmari& Hannula, Markus& Hyttinen, Jari…[et al.]. Knitted 3D Scaffolds of Polybutylene Succinate Support Human Mesenchymal Stem Cell Growth and Osteogenesis. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1213489
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213489