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Guiding the Differentiation Direction of Pancreatic Islet-Derived Stem Cells by Glycated Collagen
المؤلفون المشاركون
Duruksu, Gokhan
Aciksari, Aysegul
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-03
دولة النشر
مصر
عدد الصفحات
10
الملخص EN
The microenvironment is an important factor of stem cells regulating their maintenance, survival, and differentiation.
The glycation of proteins with reducing sugars through nonenzymatic reactions induces the collagen cross-linking, which causes tissue stiffening, which is enhanced during aging and diabetes.
In this study, we aimed to analyze the effect of glycated collagen on the stem cell culture and differentiation.
The collagen type 1 was modified by glycation with mannose, rhamnose, arabinose, and glucose.
After the culture of mesenchymal stem cells on the coated surfaces with glycated collagen, the differences in cell adhesion, proliferation, and differentiation were compared.
The results showed that the modifications did not induce apoptosis or cause cell death.
However, the culture of cells on modified collagens improved the proliferation.
It was found that the mannose-modified collagen stimulated the adipogenic differentiation of stem cells, and rhamnose-modified collagen supports the differentiation into both osteogenic and insulin-producing cells.
The low concentration of monosaccharides during glycation process improved the characteristics of the matrix protein in favor of stem cell differentiation.
Modification of the collagen by glycation might be used as a tool to improve natural polymers for material-induced stem cell differentiation in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Duruksu, Gokhan& Aciksari, Aysegul. 2018. Guiding the Differentiation Direction of Pancreatic Islet-Derived Stem Cells by Glycated Collagen. Stem Cells International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213506
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Duruksu, Gokhan& Aciksari, Aysegul. Guiding the Differentiation Direction of Pancreatic Islet-Derived Stem Cells by Glycated Collagen. Stem Cells International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1213506
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Duruksu, Gokhan& Aciksari, Aysegul. Guiding the Differentiation Direction of Pancreatic Islet-Derived Stem Cells by Glycated Collagen. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213506
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1213506
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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