Comparative Effects of Umbilical Cord- and Menstrual Blood-Derived MSCs in Repairing Acute Lung Injury
المؤلفون المشاركون
Wang, Jinfu
Ren, Haitao
Zhang, Qiang
Pan, Ruolang
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-27
دولة النشر
مصر
عدد الصفحات
9
الملخص EN
Mesenchymal stem cells (MSCs) can effectively relieve acute lung injury (ALI) in several in vivo models.
However, the underlying mechanisms and optimal sources of MSCs are unclear.
In the present study, we investigated the effects of umbilical cord- (UC-) and menstrual blood- (MB-) derived MSCs on ALI.
MSCs were transplanted into a lipopolysaccharide-induced ALI mouse model, and the therapeutic effects were determined by histological, cellular, and biochemical analyses.
Our results showed that both UCMSC and MBMSC transplantation inhibited the inflammatory response and promoted lung tissue repair.
UCMSC treatment resulted in reduced damage and inflammation in the lung tissue and enhanced protection of lung function.
Furthermore, we found that UCMSCs secreted higher levels of anti-inflammatory cytokines (interleukin-10 and keratinocyte growth factor) in ALI-related conditions, which may be due to the greater therapeutic capacity of UCMSCs compared with MBMSCs.
These findings suggest that MSCs protected the lipopolysaccharide-induced ALI model by regulating inflammation, most likely via paracrine factors.
Moreover, MSCs derived from the UC may be a promising alternative for ALI treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ren, Haitao& Zhang, Qiang& Wang, Jinfu& Pan, Ruolang. 2018. Comparative Effects of Umbilical Cord- and Menstrual Blood-Derived MSCs in Repairing Acute Lung Injury. Stem Cells International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1213585
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ren, Haitao…[et al.]. Comparative Effects of Umbilical Cord- and Menstrual Blood-Derived MSCs in Repairing Acute Lung Injury. Stem Cells International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1213585
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ren, Haitao& Zhang, Qiang& Wang, Jinfu& Pan, Ruolang. Comparative Effects of Umbilical Cord- and Menstrual Blood-Derived MSCs in Repairing Acute Lung Injury. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1213585
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1213585
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر