Comparative Effects of Umbilical Cord- and Menstrual Blood-Derived MSCs in Repairing Acute Lung Injury
Joint Authors
Wang, Jinfu
Ren, Haitao
Zhang, Qiang
Pan, Ruolang
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-27
Country of Publication
Egypt
No. of Pages
9
Abstract EN
Mesenchymal stem cells (MSCs) can effectively relieve acute lung injury (ALI) in several in vivo models.
However, the underlying mechanisms and optimal sources of MSCs are unclear.
In the present study, we investigated the effects of umbilical cord- (UC-) and menstrual blood- (MB-) derived MSCs on ALI.
MSCs were transplanted into a lipopolysaccharide-induced ALI mouse model, and the therapeutic effects were determined by histological, cellular, and biochemical analyses.
Our results showed that both UCMSC and MBMSC transplantation inhibited the inflammatory response and promoted lung tissue repair.
UCMSC treatment resulted in reduced damage and inflammation in the lung tissue and enhanced protection of lung function.
Furthermore, we found that UCMSCs secreted higher levels of anti-inflammatory cytokines (interleukin-10 and keratinocyte growth factor) in ALI-related conditions, which may be due to the greater therapeutic capacity of UCMSCs compared with MBMSCs.
These findings suggest that MSCs protected the lipopolysaccharide-induced ALI model by regulating inflammation, most likely via paracrine factors.
Moreover, MSCs derived from the UC may be a promising alternative for ALI treatment.
American Psychological Association (APA)
Ren, Haitao& Zhang, Qiang& Wang, Jinfu& Pan, Ruolang. 2018. Comparative Effects of Umbilical Cord- and Menstrual Blood-Derived MSCs in Repairing Acute Lung Injury. Stem Cells International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1213585
Modern Language Association (MLA)
Ren, Haitao…[et al.]. Comparative Effects of Umbilical Cord- and Menstrual Blood-Derived MSCs in Repairing Acute Lung Injury. Stem Cells International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1213585
American Medical Association (AMA)
Ren, Haitao& Zhang, Qiang& Wang, Jinfu& Pan, Ruolang. Comparative Effects of Umbilical Cord- and Menstrual Blood-Derived MSCs in Repairing Acute Lung Injury. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1213585
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213585