![](/images/graphics-bg.png)
Influence of Seasonality and Circulating Cytokines on Serial QuantiFERON Discordances
المؤلفون المشاركون
Graviss, Edward A.
Griffin, Marsha L.
Agarwal, Saroochi
Murphy, Melissa Zhu
Teeter, Larry D.
المصدر
Tuberculosis Research and Treatment
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-12
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objectives.
An 18-month prospective study serially tested healthcare workers (HCWs) for tuberculosis infection (TBI) and reported discordant QuantiFERON Gold In-Tube® (QFT) results in some participants.
The purpose of the current study was to investigate whether the interferon-gamma (IFN-γ) measured by QFT in discordant individuals could be influenced by other circulating cytokines that vary seasonally at the time of phlebotomy.
Methods.
The CDC funded TBESC Task Order 18 (TO18) project to assess the use of Interferon Gamma Release Assays (IGRAs), T-SPOT.TB® and QFT, compared to the tuberculin skin test (TST) for the serial testing of TBI in HCW at 4 US sites.
Unstimulated plasma from 9 discordant TO18 participants at 4 different time points from the Houston site was multiplexed to determine the association between circulating cytokines and antigen stimulated IFN-γ levels.
Results.
IL-12, IL-1β, IL-3, GCSF, and IL-7 were associated with the amount of IFN-γ measured in response to antigen stimulation.
In addition to these cytokines, a significant relationship was found between a positive QFT result and the spring season.
Conclusions.
Allergens during the spring season can result in the upregulation of IL-1β and IL-3, and this upregulation was observed with the amount of IFN-γ measured in discordant results.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Griffin, Marsha L.& Agarwal, Saroochi& Murphy, Melissa Zhu& Teeter, Larry D.& Graviss, Edward A.. 2018. Influence of Seasonality and Circulating Cytokines on Serial QuantiFERON Discordances. Tuberculosis Research and Treatment،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1215594
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Griffin, Marsha L.…[et al.]. Influence of Seasonality and Circulating Cytokines on Serial QuantiFERON Discordances. Tuberculosis Research and Treatment No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1215594
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Griffin, Marsha L.& Agarwal, Saroochi& Murphy, Melissa Zhu& Teeter, Larry D.& Graviss, Edward A.. Influence of Seasonality and Circulating Cytokines on Serial QuantiFERON Discordances. Tuberculosis Research and Treatment. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1215594
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1215594
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)