Influence of Seasonality and Circulating Cytokines on Serial QuantiFERON Discordances
Joint Authors
Graviss, Edward A.
Griffin, Marsha L.
Agarwal, Saroochi
Murphy, Melissa Zhu
Teeter, Larry D.
Source
Tuberculosis Research and Treatment
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objectives.
An 18-month prospective study serially tested healthcare workers (HCWs) for tuberculosis infection (TBI) and reported discordant QuantiFERON Gold In-Tube® (QFT) results in some participants.
The purpose of the current study was to investigate whether the interferon-gamma (IFN-γ) measured by QFT in discordant individuals could be influenced by other circulating cytokines that vary seasonally at the time of phlebotomy.
Methods.
The CDC funded TBESC Task Order 18 (TO18) project to assess the use of Interferon Gamma Release Assays (IGRAs), T-SPOT.TB® and QFT, compared to the tuberculin skin test (TST) for the serial testing of TBI in HCW at 4 US sites.
Unstimulated plasma from 9 discordant TO18 participants at 4 different time points from the Houston site was multiplexed to determine the association between circulating cytokines and antigen stimulated IFN-γ levels.
Results.
IL-12, IL-1β, IL-3, GCSF, and IL-7 were associated with the amount of IFN-γ measured in response to antigen stimulation.
In addition to these cytokines, a significant relationship was found between a positive QFT result and the spring season.
Conclusions.
Allergens during the spring season can result in the upregulation of IL-1β and IL-3, and this upregulation was observed with the amount of IFN-γ measured in discordant results.
American Psychological Association (APA)
Griffin, Marsha L.& Agarwal, Saroochi& Murphy, Melissa Zhu& Teeter, Larry D.& Graviss, Edward A.. 2018. Influence of Seasonality and Circulating Cytokines on Serial QuantiFERON Discordances. Tuberculosis Research and Treatment،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1215594
Modern Language Association (MLA)
Griffin, Marsha L.…[et al.]. Influence of Seasonality and Circulating Cytokines on Serial QuantiFERON Discordances. Tuberculosis Research and Treatment No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1215594
American Medical Association (AMA)
Griffin, Marsha L.& Agarwal, Saroochi& Murphy, Melissa Zhu& Teeter, Larry D.& Graviss, Edward A.. Influence of Seasonality and Circulating Cytokines on Serial QuantiFERON Discordances. Tuberculosis Research and Treatment. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1215594
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1215594