HER-2 Protein Overexpression in Patients with Gastric and Oesophageal Adenocarcinoma at a Tertiary Care Facility in Ghana

المؤلفون المشاركون

Adu, Patrick
Asante, Du-Bois
Akakpo, Patrick Kafui
Gyasi, Richard K.
Asmah, Richard Harry
Simpong, David Larbi
Krampah, Cecilia
Naporo, Simon
Adjei, Andrew Anthony

المصدر

The Scientific World Journal

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-03-14

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب

الملخص EN

The prognosis of gastric and oesophageal adenocarcinoma remains generally poor.

However, mounting evidence suggests a positive role of human epidermal growth factor receptor-2 (HER-2) expression in the prognosis of patients with these cancers.

In this work, the patterns of HER-2 protein expression were determined in patients with gastric or oesophageal adenocarcinoma.

Retrospectively, we reviewed records of gastric and oesophageal biopsies received from 2008 to 2012 and their corresponding archived formalin-fixed paraffin-embedded tissue blocks selected for immunohistochemical analysis.

The prevalence of gastric and oesophageal adenocarcinomas and their association with HER-2 protein overexpression were evaluated.

Gastric adenocarcinoma made up 18.79% of the gastric biopsies reviewed, and majority of these cancers occurred in males.

Regarding the tumour type, HER-2 overexpression was common in the intestinal subtype compared to the diffuse type.

Although squamous cell carcinoma was observed to be the commonest (31%) tumour type in the oesophagus compared to adenocarcinoma (8.79%), HER-2 was overexpressed in 42.9% of oesophageal adenocarcinomas, like gastric adenocarcinoma (41.4%).

There is a high prevalence of gastric and oesophageal adenocarcinoma, with significant overexpression of HER-2 in these tumours, a window of hope for the management of patients with these cancers.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Simpong, David Larbi& Asmah, Richard Harry& Krampah, Cecilia& Akakpo, Patrick Kafui& Adu, Patrick& Asante, Du-Bois…[et al.]. 2018. HER-2 Protein Overexpression in Patients with Gastric and Oesophageal Adenocarcinoma at a Tertiary Care Facility in Ghana. The Scientific World Journal،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1215603

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Simpong, David Larbi…[et al.]. HER-2 Protein Overexpression in Patients with Gastric and Oesophageal Adenocarcinoma at a Tertiary Care Facility in Ghana. The Scientific World Journal No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1215603

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Simpong, David Larbi& Asmah, Richard Harry& Krampah, Cecilia& Akakpo, Patrick Kafui& Adu, Patrick& Asante, Du-Bois…[et al.]. HER-2 Protein Overexpression in Patients with Gastric and Oesophageal Adenocarcinoma at a Tertiary Care Facility in Ghana. The Scientific World Journal. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1215603

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1215603