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HER-2 Protein Overexpression in Patients with Gastric and Oesophageal Adenocarcinoma at a Tertiary Care Facility in Ghana
Joint Authors
Adu, Patrick
Asante, Du-Bois
Akakpo, Patrick Kafui
Gyasi, Richard K.
Asmah, Richard Harry
Simpong, David Larbi
Krampah, Cecilia
Naporo, Simon
Adjei, Andrew Anthony
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The prognosis of gastric and oesophageal adenocarcinoma remains generally poor.
However, mounting evidence suggests a positive role of human epidermal growth factor receptor-2 (HER-2) expression in the prognosis of patients with these cancers.
In this work, the patterns of HER-2 protein expression were determined in patients with gastric or oesophageal adenocarcinoma.
Retrospectively, we reviewed records of gastric and oesophageal biopsies received from 2008 to 2012 and their corresponding archived formalin-fixed paraffin-embedded tissue blocks selected for immunohistochemical analysis.
The prevalence of gastric and oesophageal adenocarcinomas and their association with HER-2 protein overexpression were evaluated.
Gastric adenocarcinoma made up 18.79% of the gastric biopsies reviewed, and majority of these cancers occurred in males.
Regarding the tumour type, HER-2 overexpression was common in the intestinal subtype compared to the diffuse type.
Although squamous cell carcinoma was observed to be the commonest (31%) tumour type in the oesophagus compared to adenocarcinoma (8.79%), HER-2 was overexpressed in 42.9% of oesophageal adenocarcinomas, like gastric adenocarcinoma (41.4%).
There is a high prevalence of gastric and oesophageal adenocarcinoma, with significant overexpression of HER-2 in these tumours, a window of hope for the management of patients with these cancers.
American Psychological Association (APA)
Simpong, David Larbi& Asmah, Richard Harry& Krampah, Cecilia& Akakpo, Patrick Kafui& Adu, Patrick& Asante, Du-Bois…[et al.]. 2018. HER-2 Protein Overexpression in Patients with Gastric and Oesophageal Adenocarcinoma at a Tertiary Care Facility in Ghana. The Scientific World Journal،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1215603
Modern Language Association (MLA)
Simpong, David Larbi…[et al.]. HER-2 Protein Overexpression in Patients with Gastric and Oesophageal Adenocarcinoma at a Tertiary Care Facility in Ghana. The Scientific World Journal No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1215603
American Medical Association (AMA)
Simpong, David Larbi& Asmah, Richard Harry& Krampah, Cecilia& Akakpo, Patrick Kafui& Adu, Patrick& Asante, Du-Bois…[et al.]. HER-2 Protein Overexpression in Patients with Gastric and Oesophageal Adenocarcinoma at a Tertiary Care Facility in Ghana. The Scientific World Journal. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1215603
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1215603