Value of matrix metalloproteinase-7and vimentin as prognostic biomarkers in adenoid cystic carcinoma : Immunohistochemical study
المؤلفون المشاركون
Ali, Thair Wali
al-Kerttani, Usamah Muhammad Ghazi
Murad, Ali Hasan Ali
المصدر
Journal of Babylon University : Journal of Applied and Pure Sciences
العدد
المجلد 26، العدد 1 (31 يناير/كانون الثاني 2018)، ص ص. 140-149، 10ص.
الناشر
تاريخ النشر
2018-01-31
دولة النشر
العراق
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
matrix metalloproteinase-7 (MMP7), its primary role is to break down extracellular matrix including casein, type I, II, IV, and V gelatins, fibronectin, and proteoglycan.
The upregulation of MMP7 is associated with many malignant tumors.
Vimentin (Vim) plays an important role in malignant tumors with regard to cellular adhesion, migration and signaling.
In our current study, we have attempted to evaluate the expression of MMP7 and Vim as markers for aggressive biological behavior of AdCC.
Materials and Methods: Nineteen formalin fixed paraffin embedded blocks of AdCC were collected retrospectively were included in this study.
An immunohistochemical (IHC) staining was performed using anti MMP7 and anti Vim monoclonal antibodies.
Results: MMP7 showed significant relation with larger size tumor (P=0.003), higher grade (P=0.006).
The Vim was significantly correlated with minor salivary gland (P=0.041), larger size tumor (P=0.021), high grade (P=0.040).
Both markers revealed highly significant correlation with advanced stage (P<0.001), and positive lymph node (LN) (P<0.001).
There was a significant positive correlation between Vim and MMP7 (P=0.001).Conclusion: Both MMP7 and Vim are positively correlated with tumors of poor prognosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Murad, Ali Hasan Ali& Ali, Thair Wali& al-Kerttani, Usamah Muhammad Ghazi. 2018. Value of matrix metalloproteinase-7and vimentin as prognostic biomarkers in adenoid cystic carcinoma : Immunohistochemical study. Journal of Babylon University : Journal of Applied and Pure Sciences،Vol. 26, no. 1, pp.140-149.
https://search.emarefa.net/detail/BIM-1218036
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Murad, Ali Hasan Ali…[et al.]. Value of matrix metalloproteinase-7and vimentin as prognostic biomarkers in adenoid cystic carcinoma : Immunohistochemical study. Journal of Babylon University : Journal of Applied and Pure Sciences Vol. 26, no. 1 (2018), pp.140-149.
https://search.emarefa.net/detail/BIM-1218036
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Murad, Ali Hasan Ali& Ali, Thair Wali& al-Kerttani, Usamah Muhammad Ghazi. Value of matrix metalloproteinase-7and vimentin as prognostic biomarkers in adenoid cystic carcinoma : Immunohistochemical study. Journal of Babylon University : Journal of Applied and Pure Sciences. 2018. Vol. 26, no. 1, pp.140-149.
https://search.emarefa.net/detail/BIM-1218036
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 147-149
رقم السجل
BIM-1218036
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر