Value of matrix metalloproteinase-7and vimentin as prognostic biomarkers in adenoid cystic carcinoma : Immunohistochemical study
Joint Authors
Ali, Thair Wali
al-Kerttani, Usamah Muhammad Ghazi
Murad, Ali Hasan Ali
Source
Journal of Babylon University : Journal of Applied and Pure Sciences
Issue
Vol. 26, Issue 1 (31 Jan. 2018), pp.140-149, 10 p.
Publisher
Publication Date
2018-01-31
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Abstract EN
matrix metalloproteinase-7 (MMP7), its primary role is to break down extracellular matrix including casein, type I, II, IV, and V gelatins, fibronectin, and proteoglycan.
The upregulation of MMP7 is associated with many malignant tumors.
Vimentin (Vim) plays an important role in malignant tumors with regard to cellular adhesion, migration and signaling.
In our current study, we have attempted to evaluate the expression of MMP7 and Vim as markers for aggressive biological behavior of AdCC.
Materials and Methods: Nineteen formalin fixed paraffin embedded blocks of AdCC were collected retrospectively were included in this study.
An immunohistochemical (IHC) staining was performed using anti MMP7 and anti Vim monoclonal antibodies.
Results: MMP7 showed significant relation with larger size tumor (P=0.003), higher grade (P=0.006).
The Vim was significantly correlated with minor salivary gland (P=0.041), larger size tumor (P=0.021), high grade (P=0.040).
Both markers revealed highly significant correlation with advanced stage (P<0.001), and positive lymph node (LN) (P<0.001).
There was a significant positive correlation between Vim and MMP7 (P=0.001).Conclusion: Both MMP7 and Vim are positively correlated with tumors of poor prognosis.
American Psychological Association (APA)
Murad, Ali Hasan Ali& Ali, Thair Wali& al-Kerttani, Usamah Muhammad Ghazi. 2018. Value of matrix metalloproteinase-7and vimentin as prognostic biomarkers in adenoid cystic carcinoma : Immunohistochemical study. Journal of Babylon University : Journal of Applied and Pure Sciences،Vol. 26, no. 1, pp.140-149.
https://search.emarefa.net/detail/BIM-1218036
Modern Language Association (MLA)
Murad, Ali Hasan Ali…[et al.]. Value of matrix metalloproteinase-7and vimentin as prognostic biomarkers in adenoid cystic carcinoma : Immunohistochemical study. Journal of Babylon University : Journal of Applied and Pure Sciences Vol. 26, no. 1 (2018), pp.140-149.
https://search.emarefa.net/detail/BIM-1218036
American Medical Association (AMA)
Murad, Ali Hasan Ali& Ali, Thair Wali& al-Kerttani, Usamah Muhammad Ghazi. Value of matrix metalloproteinase-7and vimentin as prognostic biomarkers in adenoid cystic carcinoma : Immunohistochemical study. Journal of Babylon University : Journal of Applied and Pure Sciences. 2018. Vol. 26, no. 1, pp.140-149.
https://search.emarefa.net/detail/BIM-1218036
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 147-149
Record ID
BIM-1218036