Effectiveness of ketotifen in treating uremic pruritus
المؤلفون المشاركون
Amin, Wisam Ali
Abd, Basim A.
al-Mamuri, Ali Jabir
المصدر
Journal of Babylon University : Journal of Applied and Pure Sciences
العدد
المجلد 25، العدد 2 (30 يونيو/حزيران 2017)، ص ص. 761-769، 9ص.
الناشر
تاريخ النشر
2017-06-30
دولة النشر
العراق
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Introduction Among the commonest distressing complaints in patients with chronic kidney disease, is itching.
We conducted a prospective study to assess the efficacy of ketotifen, a putative.mast.cell.stabilizer, in patients with uremic itch refractory to traditional.treatment.
Materials and Methods A double-blind.randomized.trial with a crossover.design was applied on 25 patients .In all of these patients,causes of itching other than uremia had been excluded.
We divided the patients into two groups A and B ; they received either oral ketotifen, 1 mg, twice a day for 2 week or placebo for the same period .
After A one week period of washout, each group was conversely treated.
The response was assessed by the patients subjectively by a questionnaire to assess their itching is either totally relieved ,partially relieved, or still the same (no effect).
Results nine patients (36%) reported totally relieved itching with ketotifen and none (0%) with placebo (P =.003).
Partial relieve was reported in 15 (60%) and 16 (64 %), respectively.
One patient (4%) with ketotifen and nine patients (36%) with placebo showed no change in their symptoms..
Eleven patients (44%) suffered from drowsiness that decreased spontaeously in all them after average 5 days.
Conclusions in this study,we postulate that ketotifen, a putative.mast.cell.stabilizer, can be employed to relieve pruritus refractory to other traditional therapies in chronic kidney disease patients who were on maintenence hemodialysis.
A moderate dose of ketotifen was effective while safe despite its major side effect, drowsiness, which was transient and could be well accepted by uremic subjects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Mamuri, Ali Jabir& Amin, Wisam Ali& Abd, Basim A.. 2017. Effectiveness of ketotifen in treating uremic pruritus. Journal of Babylon University : Journal of Applied and Pure Sciences،Vol. 25, no. 2, pp.761-769.
https://search.emarefa.net/detail/BIM-1234970
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Mamuri, Ali Jabir…[et al.]. Effectiveness of ketotifen in treating uremic pruritus. Journal of Babylon University : Journal of Applied and Pure Sciences Vol. 25, no. 2 (2017), pp.761-769.
https://search.emarefa.net/detail/BIM-1234970
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Mamuri, Ali Jabir& Amin, Wisam Ali& Abd, Basim A.. Effectiveness of ketotifen in treating uremic pruritus. Journal of Babylon University : Journal of Applied and Pure Sciences. 2017. Vol. 25, no. 2, pp.761-769.
https://search.emarefa.net/detail/BIM-1234970
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 767-769
رقم السجل
BIM-1234970
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر