Effectiveness of ketotifen in treating uremic pruritus
Joint Authors
Amin, Wisam Ali
Abd, Basim A.
al-Mamuri, Ali Jabir
Source
Journal of Babylon University : Journal of Applied and Pure Sciences
Issue
Vol. 25, Issue 2 (30 Jun. 2017), pp.761-769, 9 p.
Publisher
Publication Date
2017-06-30
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Abstract EN
Introduction Among the commonest distressing complaints in patients with chronic kidney disease, is itching.
We conducted a prospective study to assess the efficacy of ketotifen, a putative.mast.cell.stabilizer, in patients with uremic itch refractory to traditional.treatment.
Materials and Methods A double-blind.randomized.trial with a crossover.design was applied on 25 patients .In all of these patients,causes of itching other than uremia had been excluded.
We divided the patients into two groups A and B ; they received either oral ketotifen, 1 mg, twice a day for 2 week or placebo for the same period .
After A one week period of washout, each group was conversely treated.
The response was assessed by the patients subjectively by a questionnaire to assess their itching is either totally relieved ,partially relieved, or still the same (no effect).
Results nine patients (36%) reported totally relieved itching with ketotifen and none (0%) with placebo (P =.003).
Partial relieve was reported in 15 (60%) and 16 (64 %), respectively.
One patient (4%) with ketotifen and nine patients (36%) with placebo showed no change in their symptoms..
Eleven patients (44%) suffered from drowsiness that decreased spontaeously in all them after average 5 days.
Conclusions in this study,we postulate that ketotifen, a putative.mast.cell.stabilizer, can be employed to relieve pruritus refractory to other traditional therapies in chronic kidney disease patients who were on maintenence hemodialysis.
A moderate dose of ketotifen was effective while safe despite its major side effect, drowsiness, which was transient and could be well accepted by uremic subjects.
American Psychological Association (APA)
al-Mamuri, Ali Jabir& Amin, Wisam Ali& Abd, Basim A.. 2017. Effectiveness of ketotifen in treating uremic pruritus. Journal of Babylon University : Journal of Applied and Pure Sciences،Vol. 25, no. 2, pp.761-769.
https://search.emarefa.net/detail/BIM-1234970
Modern Language Association (MLA)
al-Mamuri, Ali Jabir…[et al.]. Effectiveness of ketotifen in treating uremic pruritus. Journal of Babylon University : Journal of Applied and Pure Sciences Vol. 25, no. 2 (2017), pp.761-769.
https://search.emarefa.net/detail/BIM-1234970
American Medical Association (AMA)
al-Mamuri, Ali Jabir& Amin, Wisam Ali& Abd, Basim A.. Effectiveness of ketotifen in treating uremic pruritus. Journal of Babylon University : Journal of Applied and Pure Sciences. 2017. Vol. 25, no. 2, pp.761-769.
https://search.emarefa.net/detail/BIM-1234970
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 767-769
Record ID
BIM-1234970