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Detection immunohistochemical of P21 and P27 expression in uterine tumor
المؤلفون المشاركون
Ali, Sad Hasan Muhammad
Ahmad, Basim Shihab
Dawud, Sura Zafir
المصدر
Journal of Babylon University : Journal of Applied and Pure Sciences
العدد
المجلد 25، العدد 2 (30 يونيو/حزيران 2017)، ص ص. 662-675، 14ص.
الناشر
تاريخ النشر
2017-06-30
دولة النشر
العراق
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Background:Several studies assessed gene and protein expression of p21 in endometrial carcinoma(EC), and mention that P21 represent an important participant in EC Cell invasion and metastasis ,while some researchers indicat that there were no apparent differences in immunostaining for p21.Other studies found that p27 expression significantly reduced in the endometrial carcinoma and inactivation ofP27 proteins is a specific feature in the progression of this cancer.
Methodology: This study has used Immunohistochemistry for detection the gene expression of p21 and p27 in tissue specimens from 70 hysterectomized patients diagnosed with malignant uterine tumors (30 cases), non-malignant uterine tumors (25 cases),and 15 cases as control tissues groups.
Results: The results of moleculare detection of P21 revealed12 (40%) in malignant uterine tumor 8(32%) non-malignant uterine tumor and 5(33.3%) in control groups and low expression of P27 revealed in all groups :5 (16.7%) in malignant uterine tumor 6(24%) non-malignant uterine tumor and 2(13.3%) in control groups.
Conclusions: Decrease in expression of P21 was found mostly in malignant endometrial uterine tumors and this expressions occur could have correlated to the an early events of their tumorgenesis while low expression of P27 in hysterectomized patients mostly appear in non-malignant uterine tumors at the endometrial sites.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ali, Sad Hasan Muhammad& Ahmad, Basim Shihab& Dawud, Sura Zafir. 2017. Detection immunohistochemical of P21 and P27 expression in uterine tumor. Journal of Babylon University : Journal of Applied and Pure Sciences،Vol. 25, no. 2, pp.662-675.
https://search.emarefa.net/detail/BIM-1235100
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ali, Sad Hasan Muhammad…[et al.]. Detection immunohistochemical of P21 and P27 expression in uterine tumor. Journal of Babylon University : Journal of Applied and Pure Sciences Vol. 25, no. 2 (2017), pp.662-675.
https://search.emarefa.net/detail/BIM-1235100
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ali, Sad Hasan Muhammad& Ahmad, Basim Shihab& Dawud, Sura Zafir. Detection immunohistochemical of P21 and P27 expression in uterine tumor. Journal of Babylon University : Journal of Applied and Pure Sciences. 2017. Vol. 25, no. 2, pp.662-675.
https://search.emarefa.net/detail/BIM-1235100
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 674-675
رقم السجل
BIM-1235100
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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