Detection immunohistochemical of P21 and P27 expression in uterine tumor
Joint Authors
Ali, Sad Hasan Muhammad
Ahmad, Basim Shihab
Dawud, Sura Zafir
Source
Journal of Babylon University : Journal of Applied and Pure Sciences
Issue
Vol. 25, Issue 2 (30 Jun. 2017), pp.662-675, 14 p.
Publisher
Publication Date
2017-06-30
Country of Publication
Iraq
No. of Pages
14
Main Subjects
Abstract EN
Background:Several studies assessed gene and protein expression of p21 in endometrial carcinoma(EC), and mention that P21 represent an important participant in EC Cell invasion and metastasis ,while some researchers indicat that there were no apparent differences in immunostaining for p21.Other studies found that p27 expression significantly reduced in the endometrial carcinoma and inactivation ofP27 proteins is a specific feature in the progression of this cancer.
Methodology: This study has used Immunohistochemistry for detection the gene expression of p21 and p27 in tissue specimens from 70 hysterectomized patients diagnosed with malignant uterine tumors (30 cases), non-malignant uterine tumors (25 cases),and 15 cases as control tissues groups.
Results: The results of moleculare detection of P21 revealed12 (40%) in malignant uterine tumor 8(32%) non-malignant uterine tumor and 5(33.3%) in control groups and low expression of P27 revealed in all groups :5 (16.7%) in malignant uterine tumor 6(24%) non-malignant uterine tumor and 2(13.3%) in control groups.
Conclusions: Decrease in expression of P21 was found mostly in malignant endometrial uterine tumors and this expressions occur could have correlated to the an early events of their tumorgenesis while low expression of P27 in hysterectomized patients mostly appear in non-malignant uterine tumors at the endometrial sites.
American Psychological Association (APA)
Ali, Sad Hasan Muhammad& Ahmad, Basim Shihab& Dawud, Sura Zafir. 2017. Detection immunohistochemical of P21 and P27 expression in uterine tumor. Journal of Babylon University : Journal of Applied and Pure Sciences،Vol. 25, no. 2, pp.662-675.
https://search.emarefa.net/detail/BIM-1235100
Modern Language Association (MLA)
Ali, Sad Hasan Muhammad…[et al.]. Detection immunohistochemical of P21 and P27 expression in uterine tumor. Journal of Babylon University : Journal of Applied and Pure Sciences Vol. 25, no. 2 (2017), pp.662-675.
https://search.emarefa.net/detail/BIM-1235100
American Medical Association (AMA)
Ali, Sad Hasan Muhammad& Ahmad, Basim Shihab& Dawud, Sura Zafir. Detection immunohistochemical of P21 and P27 expression in uterine tumor. Journal of Babylon University : Journal of Applied and Pure Sciences. 2017. Vol. 25, no. 2, pp.662-675.
https://search.emarefa.net/detail/BIM-1235100
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 674-675
Record ID
BIM-1235100