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Correlation between serum sclerostin level and bone density status in children on regular hemodialysis
المؤلفون المشاركون
Zayn al-Abidin, Maha
Abu Dhahab, Zakiyah
Ahmad, Hibah
Abd al-Salam, Manal
Mahmud, Iman
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 30، العدد 5 (31 أكتوبر/تشرين الأول 2019)، ص ص. 1022-1031، 10ص.
الناشر
تاريخ النشر
2019-10-31
دولة النشر
السعودية
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
-Bone disease is frequently observed in chronic kidney disease (CKD) and increases a patient’s risk for fracture.
Sclerostin is an osteocyte-derived negative regulator of bone formation.
We aimed to assess serum sclerostin level as a bone marker in children with CKD on regular hemodialysis (HD) and detect the association between this and bone density status.
This cross-sectional comparative study was conducted on 25 children with CKD on HD and 25 ageand sex-matched healthy children, as controls.
Their ages ranged from 4 to 18 years.
Serum sclerostin levels were measured and dual-energy X-ray absorptiometry scan was performed in the same line with the traditional bone markers.
There was a significant increase in serum sclerostin level in patients (1.754 ± 1.31 ng/mL) compared to controls (0.290 ± 0.074 ng/mL) with P = 0.001.
Nine patients (36%) had low bone mineral density (BMD) with z score under −2.0, eight of whom had low BMD in both the neck of femur and lumbar spines.
There was a significant increase in serum sclerostin levels in the patient-group with low BMD (2.38 ± 0.85 ng/mL) compared with patients with normal BMD (1.4 ± 0.98 ng/mL) (P = 0.001).
A significant positive correlation was found between serum sclerostin level and alkaline phosphtase, parathormone with negative correlation with serum calcium.
Sclerostin was 100% specific and sensitive in predicting CKD-mineral and bone disorder.
Elevated sclerostin levels were consistent with low BMD and appear to be an independent predictor of reduced BMD in children on regular HD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Salam, Manal& Zayn al-Abidin, Maha& Mahmud, Iman& Abu Dhahab, Zakiyah& Ahmad, Hibah. 2019. Correlation between serum sclerostin level and bone density status in children on regular hemodialysis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 30, no. 5, pp.1022-1031.
https://search.emarefa.net/detail/BIM-1256228
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Salam, Manal…[et al.]. Correlation between serum sclerostin level and bone density status in children on regular hemodialysis. Saudi Journal of Kidney Diseases and Transplantation Vol. 30, no. 5 (Sep. / Oct. 2019), pp.1022-1031.
https://search.emarefa.net/detail/BIM-1256228
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Salam, Manal& Zayn al-Abidin, Maha& Mahmud, Iman& Abu Dhahab, Zakiyah& Ahmad, Hibah. Correlation between serum sclerostin level and bone density status in children on regular hemodialysis. Saudi Journal of Kidney Diseases and Transplantation. 2019. Vol. 30, no. 5, pp.1022-1031.
https://search.emarefa.net/detail/BIM-1256228
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1030-1031
رقم السجل
BIM-1256228
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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