Correlation between serum sclerostin level and bone density status in children on regular hemodialysis
Joint Authors
Zayn al-Abidin, Maha
Abu Dhahab, Zakiyah
Ahmad, Hibah
Abd al-Salam, Manal
Mahmud, Iman
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 30, Issue 5 (31 Oct. 2019), pp.1022-1031, 10 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2019-10-31
Country of Publication
Saudi Arabia
No. of Pages
10
Main Subjects
Abstract EN
-Bone disease is frequently observed in chronic kidney disease (CKD) and increases a patient’s risk for fracture.
Sclerostin is an osteocyte-derived negative regulator of bone formation.
We aimed to assess serum sclerostin level as a bone marker in children with CKD on regular hemodialysis (HD) and detect the association between this and bone density status.
This cross-sectional comparative study was conducted on 25 children with CKD on HD and 25 ageand sex-matched healthy children, as controls.
Their ages ranged from 4 to 18 years.
Serum sclerostin levels were measured and dual-energy X-ray absorptiometry scan was performed in the same line with the traditional bone markers.
There was a significant increase in serum sclerostin level in patients (1.754 ± 1.31 ng/mL) compared to controls (0.290 ± 0.074 ng/mL) with P = 0.001.
Nine patients (36%) had low bone mineral density (BMD) with z score under −2.0, eight of whom had low BMD in both the neck of femur and lumbar spines.
There was a significant increase in serum sclerostin levels in the patient-group with low BMD (2.38 ± 0.85 ng/mL) compared with patients with normal BMD (1.4 ± 0.98 ng/mL) (P = 0.001).
A significant positive correlation was found between serum sclerostin level and alkaline phosphtase, parathormone with negative correlation with serum calcium.
Sclerostin was 100% specific and sensitive in predicting CKD-mineral and bone disorder.
Elevated sclerostin levels were consistent with low BMD and appear to be an independent predictor of reduced BMD in children on regular HD.
American Psychological Association (APA)
Abd al-Salam, Manal& Zayn al-Abidin, Maha& Mahmud, Iman& Abu Dhahab, Zakiyah& Ahmad, Hibah. 2019. Correlation between serum sclerostin level and bone density status in children on regular hemodialysis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 30, no. 5, pp.1022-1031.
https://search.emarefa.net/detail/BIM-1256228
Modern Language Association (MLA)
Abd al-Salam, Manal…[et al.]. Correlation between serum sclerostin level and bone density status in children on regular hemodialysis. Saudi Journal of Kidney Diseases and Transplantation Vol. 30, no. 5 (Sep. / Oct. 2019), pp.1022-1031.
https://search.emarefa.net/detail/BIM-1256228
American Medical Association (AMA)
Abd al-Salam, Manal& Zayn al-Abidin, Maha& Mahmud, Iman& Abu Dhahab, Zakiyah& Ahmad, Hibah. Correlation between serum sclerostin level and bone density status in children on regular hemodialysis. Saudi Journal of Kidney Diseases and Transplantation. 2019. Vol. 30, no. 5, pp.1022-1031.
https://search.emarefa.net/detail/BIM-1256228
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1030-1031
Record ID
BIM-1256228