Protective role of curcumin, glucosamine and vitamin C on oxidative stress, biochemical and histopathological alterations induced by levofloxacin
المؤلفون المشاركون
Abd al-Fadil, Husni
Buhayri, Amani
Abd al-Ghani, Hibah M.
Amaym, Iman M.
Muhammad, Ahmad A.
المصدر
Alexandria Journal of Veterinary Sciences
العدد
المجلد 62، العدد 1 (31 يوليو/تموز 2019)، ص ص. 182-193، 12ص.
الناشر
جامعة الإسكندرية كلية الطب البيطري
تاريخ النشر
2019-07-31
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Levofloxacin is considered a strong weapon against several bacterial infections but its serious side effects limit its use.
Curcumin, glucosamine hydrochloride (Gls) and vitamin C (Vit C) have strong effective properties.
Hence, the study was carried out to assess their protective roles on levofloxacin adverse effects in immature albino rats.
Fifty immature male albino rats were divided into five equal groups: I- Control group (received sterile saline solution) orally; II- Levofloxacin group (10mg/kg b.wt) intraperitoneally; III- Levofloxacin + curcumin (200mg/kg b.wt) orally; IV- Levofloxacin + Gls (500mg/kg b.wt) orally; V- Levofloxacin + Vit C (100mg/kg b.wt) intraperitoneally.
Rats were euthanized on zero day and 14 days post treatment.
The degree of protection was measured using calcium (Ca), phosphorus (P), alkaline phosphatase (ALP) and oxidative biomarkers levels.
Furthermore, specimens from tendon, joint, ligament and cartilage were collected and subjected to routine histological technique.
Levofloxacin significantly decreased Ca concentration and increased P level and ALP activity.
Co-administration of curcumin, Gls and/or Vit C restored these biochemical alterations and improved antioxidant defense system.
Levofloxacin produced degeneration of collagen fibers of tendons, necrosis of chondrocytes and destruction to lacunae of articular cartilage of joint, degeneration of collagen bundles of ligaments.
Curcumin, Gls and/or Vit C were also markedly ameliorated histopathological effect of levofloxacin.
In conclusion, curcumin, Gls and/or Vit C exerted protective actions against levofloxacin adverse effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Fadil, Husni& Muhammad, Ahmad A.& Buhayri, Amani& Abd al-Ghani, Hibah M.& Amaym, Iman M.. 2019. Protective role of curcumin, glucosamine and vitamin C on oxidative stress, biochemical and histopathological alterations induced by levofloxacin. Alexandria Journal of Veterinary Sciences،Vol. 62, no. 1, pp.182-193.
https://search.emarefa.net/detail/BIM-1323585
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muhammad, Ahmad A.…[et al.]. Protective role of curcumin, glucosamine and vitamin C on oxidative stress, biochemical and histopathological alterations induced by levofloxacin. Alexandria Journal of Veterinary Sciences Vol. 62, no. 1 (Jul. 2019), pp.182-193.
https://search.emarefa.net/detail/BIM-1323585
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Fadil, Husni& Muhammad, Ahmad A.& Buhayri, Amani& Abd al-Ghani, Hibah M.& Amaym, Iman M.. Protective role of curcumin, glucosamine and vitamin C on oxidative stress, biochemical and histopathological alterations induced by levofloxacin. Alexandria Journal of Veterinary Sciences. 2019. Vol. 62, no. 1, pp.182-193.
https://search.emarefa.net/detail/BIM-1323585
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 190-193
رقم السجل
BIM-1323585
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر