Protective role of curcumin, glucosamine and vitamin C on oxidative stress, biochemical and histopathological alterations induced by levofloxacin
Joint Authors
Abd al-Fadil, Husni
Buhayri, Amani
Abd al-Ghani, Hibah M.
Amaym, Iman M.
Muhammad, Ahmad A.
Source
Alexandria Journal of Veterinary Sciences
Issue
Vol. 62, Issue 1 (31 Jul. 2019), pp.182-193, 12 p.
Publisher
Alexandria University Faculty of Veterinary Medicine
Publication Date
2019-07-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Levofloxacin is considered a strong weapon against several bacterial infections but its serious side effects limit its use.
Curcumin, glucosamine hydrochloride (Gls) and vitamin C (Vit C) have strong effective properties.
Hence, the study was carried out to assess their protective roles on levofloxacin adverse effects in immature albino rats.
Fifty immature male albino rats were divided into five equal groups: I- Control group (received sterile saline solution) orally; II- Levofloxacin group (10mg/kg b.wt) intraperitoneally; III- Levofloxacin + curcumin (200mg/kg b.wt) orally; IV- Levofloxacin + Gls (500mg/kg b.wt) orally; V- Levofloxacin + Vit C (100mg/kg b.wt) intraperitoneally.
Rats were euthanized on zero day and 14 days post treatment.
The degree of protection was measured using calcium (Ca), phosphorus (P), alkaline phosphatase (ALP) and oxidative biomarkers levels.
Furthermore, specimens from tendon, joint, ligament and cartilage were collected and subjected to routine histological technique.
Levofloxacin significantly decreased Ca concentration and increased P level and ALP activity.
Co-administration of curcumin, Gls and/or Vit C restored these biochemical alterations and improved antioxidant defense system.
Levofloxacin produced degeneration of collagen fibers of tendons, necrosis of chondrocytes and destruction to lacunae of articular cartilage of joint, degeneration of collagen bundles of ligaments.
Curcumin, Gls and/or Vit C were also markedly ameliorated histopathological effect of levofloxacin.
In conclusion, curcumin, Gls and/or Vit C exerted protective actions against levofloxacin adverse effects.
American Psychological Association (APA)
Abd al-Fadil, Husni& Muhammad, Ahmad A.& Buhayri, Amani& Abd al-Ghani, Hibah M.& Amaym, Iman M.. 2019. Protective role of curcumin, glucosamine and vitamin C on oxidative stress, biochemical and histopathological alterations induced by levofloxacin. Alexandria Journal of Veterinary Sciences،Vol. 62, no. 1, pp.182-193.
https://search.emarefa.net/detail/BIM-1323585
Modern Language Association (MLA)
Muhammad, Ahmad A.…[et al.]. Protective role of curcumin, glucosamine and vitamin C on oxidative stress, biochemical and histopathological alterations induced by levofloxacin. Alexandria Journal of Veterinary Sciences Vol. 62, no. 1 (Jul. 2019), pp.182-193.
https://search.emarefa.net/detail/BIM-1323585
American Medical Association (AMA)
Abd al-Fadil, Husni& Muhammad, Ahmad A.& Buhayri, Amani& Abd al-Ghani, Hibah M.& Amaym, Iman M.. Protective role of curcumin, glucosamine and vitamin C on oxidative stress, biochemical and histopathological alterations induced by levofloxacin. Alexandria Journal of Veterinary Sciences. 2019. Vol. 62, no. 1, pp.182-193.
https://search.emarefa.net/detail/BIM-1323585
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 190-193
Record ID
BIM-1323585