The potential ameliorative effect of Nano-zinc and zinc against copper hepatorenal toxicosis in rats
المؤلفون المشاركون
Abu Shawq, Asma M.
Oda, Samah S.
al-Bulayhi, Samar S.
المصدر
Alexandria Journal of Veterinary Sciences
العدد
المجلد 57، العدد 1 (30 إبريل/نيسان 2018)، ص ص. 148-160، 13ص.
الناشر
جامعة الإسكندرية كلية الطب البيطري
تاريخ النشر
2018-04-30
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
This study was designed to evaluate the effect of Nano-Zinc (N-Zn) and Zinc (Zn) against copper (Cu) toxicosis in rats.
Sixty male albino rats were randomly divided into 6 groups (n=10); control group, Cu-treated group: orally received CuSo4 (100 mg/kg bwt/day ), N-Zn-treated group: intraperitoneally (IP) injected with N-ZnO (5 mg/kg bwt/day), Zn-treated group: IP injected with ZnO (5 mg/kg bwt/day), Cu+N-Zn - and Cu+Zn -treated groups received the same previous doses and routes.
All the experimental treatments were given 3 times / week and continued for eight weeks.
Results showed that Cu- treated group caused a significant decrease in body weight and a significant increase in relative liver and kidney weights.
Also, Cu caused a significant decrease in red blood cells (RBCs) count, hemoglobin (Hb) concentration, mean corpuscular hemoglobin concentration (MCHC) and platelets count with a significant increase in mean corpuscular volume (MCV) without any changes in leukocytic count.
Biochemical analysis showed a significant elevation in serum liver enzymes, total and indirect bilirubin with a significant decrease in serum levels of total proteins and albumin.
Also, there was a significant elevation in serum urea and creatinine levels.
Cu induced a significant increase in renal and hepatic malondialdhyde (MDA) and a significant decrease in reduced glutathione (GSH).
Histopathologically, Cu revealed severe degenerative and necrotic lesions in the livers and kidneys.
N-Zn and Zn- treatments attenuated Cu-induced oxidative damage, alterations in the liver and kidney function tests and histopathology.
Moreover, Zn treatment showed better protection against Cu-induced toxicity as compared to N-Zn.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abu Shawq, Asma M.& Oda, Samah S.& al-Bulayhi, Samar S.. 2018. The potential ameliorative effect of Nano-zinc and zinc against copper hepatorenal toxicosis in rats. Alexandria Journal of Veterinary Sciences،Vol. 57, no. 1, pp.148-160.
https://search.emarefa.net/detail/BIM-1330085
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abu Shawq, Asma M.…[et al.]. The potential ameliorative effect of Nano-zinc and zinc against copper hepatorenal toxicosis in rats. Alexandria Journal of Veterinary Sciences Vol. 57, no. 1 (Apr. 2018), pp.148-160.
https://search.emarefa.net/detail/BIM-1330085
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abu Shawq, Asma M.& Oda, Samah S.& al-Bulayhi, Samar S.. The potential ameliorative effect of Nano-zinc and zinc against copper hepatorenal toxicosis in rats. Alexandria Journal of Veterinary Sciences. 2018. Vol. 57, no. 1, pp.148-160.
https://search.emarefa.net/detail/BIM-1330085
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 157-160
رقم السجل
BIM-1330085
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر